Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Review Article Volume 9 Issue 11

The Mind-Gut Connection: Nutraceutical and Probiotic Strategies for Psychological Resilience

Abhinandan Patil1, Firoj A Tamboli2*, Suraj S Kalyankar3, Omkar S Mane3, Tejas V Kumbhar3, Prathmesh Y Khandare3, Dattatray K Kokare3, Pratik N Gaikwad3 and Pratiksha S Teli4

1Department of Pharmaceutics, D. Y. Patil Education Society, (Deemed to be University), Maharashtra, India
2Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Near Chitra Nagari, Maharashtra, India
3UG Students, Bharati Vidyapeeth College of Pharmacy, Near Chitra Nagari, Maharashtra, India
4Department of Pharmacognosy, Ashokrao Mane College of Pharmacy, Peth- vadgaon, India

*Corresponding Author: Firoj A Tamboli; Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Near Chitra Nagari, Maharashtra, India.

Received: September 16, 2025; Published: October 28, 2025

Abstract

The gut-brain axis, a two-way communication network connecting the brain's emotional and cognitive regions with the intestinal tract's function, has been clearly proven by emerging science. The groundbreaking role that psychobiotics-probiotics that have positive effects on mental health-and nutraceuticals play in regulating this relationship is examined in this article. We'll go into detail about how certain nutritional approaches, such as particular probiotic strains, anti-inflammatory botanicals, and neuro-supportive micronutrients, can have a positive impact on mood, stress response, and cognitive function. This provides an additional avenue for enhancing psychological resilience and mental health.

Keywords: Gut; Mind; Nutraceuticals; Probiotics; Psychological Resilience

References

  1. Williams RJ Spencer JPE. “Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease”. Free Radical Biology and Medicine 52 (2012): 35-45.
  2. Vauzour D., et al. “The neuroprotective potential of flavonoids: A multiplicity of effects”. Genes and Nutrition 3 (2008): 115-126.
  3. Witte AV., et al. “Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults”. The Journal of Neuroscience 34 (2014): 7862-7870.
  4. Scholey AB., et al. “Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort”. Journal of Psychopharmacology 24 (2010): 1505-1514.
  5. Nehlig A. “Is caffeine a cognitive enhancer?” Journal of Alzheimer’s Disease 20 (2010): S85-S89.
  6. Scholey AB., et al. “Acute neurocognitive effects of epigallocatechin gallate (EGCG)”. Appetite 58 (2012): 767-770.
  7. Wightman EL., et al. “Epigallocatechin gallate, cerebral blood flow parameters, cognitive performance, and mood in healthy humans: A double-blind, placebo-controlled, crossover investigation”. American Journal of Clinical Nutrition 95 (2012): 916-923.
  8. Commenges D., et al. “Intake of flavonoids and risk of dementia”. European Journal of Epidemiology 16 (2000): 357-363.
  9. Chan A., et al. “Efficacy of a vitamin/nutriceutical formulation for moderate-stage to later-stage Alzheimer’s disease: A placebo-controlled pilot study”. American Journal of Alzheimer’s Disease and Other Dementias 23 (2008): 571-579.
  10. Ide K., et al. “Green tea consumption affects cognitive dysfunction in the elderly: A pilot study”. Nutrients 6 (2014): 4032-4042.
  11. Desideri G., et al. “Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment”. Hypertension 60 (2012) 794-801.
  12. Brickman AM., et al. “Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults”. Nature Neuroscience 17 (2014): 1798-1803.
  13. Pase MP., et al. “Cocoa polyphenols enhance positive mood states but not cognitive performance: A randomized, placebo-controlled trial”. Journal of Psychopharmacology 27 (2013): 451-458.
  14. Macready AL., et al. “Flavonoids and cognitive function: A review of human randomized controlled trial studies and recommendations for future studies”. Genes and Nutrition 4 (2009): 227-242.
  15. Lamport DJ., et al. “Fruits, vegetables, 100% juices, and cognitive function”. Nutrition Reviews 72 (2014): 774-789.
  16. Lamport DJ., et al. “Fruits, vegetables, 100% juices, and cognitive function”. Nutrition Reviews 72 (2014): 774-789.
  17. Krikorian R., et al. “Blueberry supplementation improves memory in older adults”. Journal of Agricultural and Food Chemistry 58 (2010): 3996-4000.
  18. Bensalem J., et al. “Cognitive and mood effects in healthy elderly participants of a dietary supplement containing high-polyphenol grape and blueberry extract: A randomized, double-blind, placebo-controlled trial”. Journal of Alzheimer’s Disease 54 (2016): 1249-1263.
  19. Rendeiro C., et al. “Flavonoids as modulators of memory and learning: Molecular interactions resulting in behavioural effects”. Proceedings of the Nutrition Society 71 (2012): 246-262.
  20. Joseph JA., et al. “Reversing the deleterious effects of aging on neuronal communication and behavior: Beneficial properties of fruit polyphenolic compounds”. American Journal of Clinical Nutrition 81 (2005) 313S-316S.
  21. Letenneur L., et al. “Flavonoid intake and cognitive decline over a 10-year period”. American Journal of Epidemiology 165 (2007): 1364-1371.
  22. Nurk E., et al. “Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance”. Journal of Nutrition 139 (2009): 120-127.
  23. Whyte AR., et al. “A randomized, double-blinded, placebo-controlled study to compare the cognitive and mood effects of two different blueberry formulations in healthy older adults”. Nutrients 10 (2018): 660.
  24. Patil S., et al. “Formulation and evaluation of a licorice-resveratrol lollipop for targeting Streptococcus mutans biofilm and antimicrobial resistance”. Infection and Drug Resistance 18 (2025): 3933-3946.
  25. Shingade JA., et al. “Electrostatically assembled maghemite nanoparticles-Lactobacillus plantarum: A novel hybrid for enhanced antioxidant, antimicrobial, and antibiofilm efficacy”. Bioresource Technology 430 (2025): 132538.
  26. Manikyam HK., et al. “Steroidal glycosides from Mallotus philippensis induce apoptosis in MCF-7 breast cancer cells via MTT and DAPI assays”. Asian Journal of Natural Product Biochemistry 1 (2025): 47-51.
  27. Wang J., et al. “Rational design of allosteric inhibitors targeting C797S mutant EGFR in NSCLC: An integrative in silico and in vitro study”. Frontiers in Oncology 15 (2025): 1590779.
  28. Tamboli FA., et al. “Nano Nutraceuticals: Revolutionizing the Future of Health Supplements”. Biomedical and Pharmacology Journal 1 (2025): 459-470.
  29. Manikyam HK., et al. “A review on cancer cell metabolism of fats: Insights into altered lipid homeostasis”. Disease Research2 (2024): 97-107.
  30. Manikyam HK., et al. “High-throughput in silico drug screen against Mpox targeted proteins in comparison with repurposed antiviral drugs against natural compounds”. Journal of Pharmaceutical Research International 11 (2024): 41-52.
  31. Wang L., et al. “Exploring anticancer potential of Lactobacillus strains: Insights into cytotoxicity and apoptotic mechanisms on HCT 115 cancer cells”. Biologics: Targets and Therapy 18 (2024): 285-295.

Citation

Citation: Firoj A Tamboli., et al. “The Mind-Gut Connection: Nutraceutical and Probiotic Strategies for Psychological Resilience".Acta Scientific Nutritional Health 9.11 (2025): 44-54.

Copyright

Copyright: © 2025 Firoj A Tamboli., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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