Arti S Budhawale¹, Firoj A Tamboli²*, Ishwari S Deshmukh¹, Shruti V Chavan¹, Sonal A Dhodi¹, Priyadarshani D Kothawale¹, Samrudhi S Kamble¹, Yash S Tote¹ and Rinku L Gavit¹

¹UG Students, B. Pharmacy, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India
²Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India

*Corresponding Author: Firoj A Tamboli, Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India.

Received: May 14, 2025; Published: June 24, 2025

Abstract

The increasing awareness of the adverse effects of synthetic sunscreens, including skin irritation, environmental toxicity, and potential endocrine disruption, has driven the search for natural alternatives. Plants, being rich sources of bioactive compounds, have emerged as promising candidates for natural photoprotection. Many plant species possess secondary metabolites such as flavonoids, phenolic acids, tannins, and essential oils that exhibit significant ultraviolet (UV) absorption properties, antioxidant activity, and skin-soothing effects. This study explores the potential of various medicinal and cosmetic plants traditionally used for skin care, focusing on their ability to offer sunscreen-protecting activity. Notable examples include Aloe vera, Camellia sinensis (green tea), Curcuma longa (turmeric), Ocimum sanctum (holy basil), Glycyrrhiza glabra (licorice), and Helianthus annuus (sunflower). These plants not only shield the skin from harmful UVA and UVB rays but also help reduce oxidative stress and inflammation caused by sun exposure. In vitro and in vivo studies have demonstrated that extracts from these plants can significantly enhance the Sun Protection Factor (SPF) when used alone or in combination with conventional sunscreen agents. Additionally, their incorporation into topical formulations supports the development of eco-friendly, biocompatible sunscreens with fewer side effects. Overall, plant-based sunscreens offer a sustainable and skin-friendly alternative to chemical formulations, with growing commercial and therapeutic potential. Further research into extraction methods, compound standardization, and clinical efficacy will pave the way for integrating these botanicals into mainstream photoprotective products.

Keywords: Photoprotectors; Nutritional Phytochemicals; Eco-Friendly; UV Radiation

References

1. S Sen and R Chakraborty. “Toward the integration and advancement of herbal medicine: a focus on Traditional Indian medicine”. Target Ther 5 (2015): 33-44.
2. Battistin M., et al. “A new approach to UV protection by direct surface functionalization of TiO2 with the antioxidant polyphenol dihydroxyphenyl benzimidazole carboxylic acid”. Nanomaterials (Basel) 2 ( 2020): 231‐249.
3. Li L., et al. “Natural products and extracts from plants as natural UV filters for sunscreens: A review”. Animal Models and Experimental Medicine3 (2023): 183-195.
4. Verma A., et al. “Skin protection from solar ultraviolet radiation using natural compounds: A Review”. Environmental Chemistry Letters 22 (2015): 273-295.
5. A Regallay C., et al. “Effectiveness of sunscreen against melanoma”. Revue Médicale Suisse 635 (2019): 198-201.
6. González Maglio DH., et al. “Sunlight Effects on Immune System: Is There Something Else in addition to UV-Induced Immunosuppression?” BioMed Research International 2016 (2016): 1934518.
7. Pääkkonen R., et al. “Examples of UV Measurements under 400 kV Powerlines in Finland”. PIERS Proceedings (2013).
8. Latha M., et al. “Sunscreening agents: A review”. The Journal of Clinical and Aesthetic Dermatology 1 ( 2013): 16.
9. Mukund Manikrao Donglikar and Sharada Laxman Deore. “Sunscreens A Review”. Pharmacognosy Journal3 (2016): 171-175.
10. Peter KV and Babu KN. “Introduction to herbs and spices: medicinal uses and sunscreen activity In Handbook of herbs and spices (2012) Jan 1 (pp. 1-16)”. Woodhead Publish Donglikar, M. M., and Deore, S. L. (2016).
11. He H., et al. “Natural components in sunscreens: Topical formulations with a sun protection factor (SPF)”. Biomedicine and Pharmacotherapy 134 ( 2020) :111-161.
12. Donglikar MM and Deore SL. “Sunscreens: A review”. Pharmacognosy Journals3 (2016): 71-179.
13. Rajendra Jangde and Daharwal SJ. “Herbal Sunscreen; An Overview”. Research Journal of Topical and Cosmetic Sciences2 (2011) : 35-39.
14. Goyal J and Verma PK. “An Overview of Biosynthetic Pathway and Therapeutic Potential of Rutin”. Mini-Reviews in Medicinal Chemistry 23 (2023): 1451-1460.
15. Heim KE., et al. “Flavonoid Antioxidants: Chemistry, Metabolism and Structure-Activity Relationships”. The Journal of Nutritional Biochemistry 13 (2002): 572-584.
16. Hoang HT., et al. “Natural Antioxidants from Plant Extracts in Skincare Cosmetics: Recent Applications, Challenges and Perspectives”. Cosmetics 8 (2021).
17. Cizmazora B., et al. “Flavonoids as Promising Natural Compounds in the Prevention andTreatment of Selected Skin Diseases”. International Journal of Molecular Sciences 24 (2023): 6324.
18. Torres-Contreras AM., et al. “Plant Secondary Metabolites against Skin Photodamage”. Mexican Plants, a Potential Source of UV-Radiation Protectant Molecules”. Plants 11 (2022): 220.
19. KC Rangel., et al. “Gaspar, Assessment of the photoprotective potential and toxicity of Antarctic red macroalgae extracts from Curdiea racovitzae and Iridaea cordata for cosmetic use”. Algal Research 50 (2020): 101984.
20. G Bhandari and S Baurai. “Assessment of in vitro sun protection factor of plant extracts by ultraviolet spectroscopy method”. The journal Universities' Journal of Phytochemistry and Ayurvedic Heights 2 (2020): 20-25.
21. Donglikar MM and Deore SL. “Sunscreens: a review”. The Pharmaceutical Journal3 (2016): 171- 179.
22. Mishra AK., et al. “Herbal cosmeceuticals for photoprotec-tion from ultraviolet B radiation: A review”. Tropical Journal of Pharmaceutical Research 3 (2011): 351-360.
23. Donglikar MM., et al. “Turkish Journal of Pharmaceutical Sciences 17 (2020): 285-292.
24. Olsen CM., et al. “Prevention of DNA damage in human skin by topical sunscreens”. Photodermatology, Photoimmunology and Photomedicine 33(2017): 135-142.
25. Bettadaiah BK., et al. “Key phenolic components of ginger and their derivatives: Synthesis and inhibitory action on quorum sensing”. Food Chemistry 159 (2014): 451-457.
26. Citronberg J., et al. “Results of a pilot, randomized, controlled study on the effects of ginger supplementation on cell-cycle biomarkers in the normal-looking colonic mucosa of patients at elevated risk for colorectal cancer”. Cancer Prevention Research 6 (2013): 271-281.
27. Chang K., et al. “10-Gingerol is primarily responsible for fresh ginger's anti-neuroinflammatory properties”. Food Chemistry3 (2013): 3183-3191.
28. Goularte JF., et al. “Impact of adding ginger and turmeric rhizomes to the diet on the angiotensin-1 converting enzyme (ACE) and arginase activity in rats with L-NAME-induced hypertension”. Journal of Functional Foods 17 (2015): 792-801.
29. Thimmegowda NR., et al. “In rats fed a high-fat diet, gingerenone A, a polyphenol found in ginger, reduces inflammation of adipose tissue and obesity”. Molecular Nutrition and Food Research9 (2017) : 1700139.
30. Cheng Y., et al. “The strong ginger chemicals 6-paradol and 6-shogaol encourage adipocytes and myotubes to use glucose, while 6-paradol lowers blood glucose in mice fed a high-fat diet”. International Journal of Molecular Sciences 1 (2017): 168.
31. Walstab J., et al. “Non-competitively, ginger and its strong ingredients prevent the activation of both native and human recombinant 5-HT3 receptors in enteric neurons”. Neurogastroenterology and Motility5 (2013): 439-447.
32. Zhang Y., et al. “Effects of ginger and its ingredients on calcium regulation and the relaxing of smooth muscles in the airways”. American Journal of Respiratory Cell and Molecular Biology2 (2013): 157-163.
33. Tyagi AK and Prasad S. “The potential of ginger and its components to prevent and treat gastrointestinal cancer”. Gastroenterology Research and Practice ( 2015): 142979.
34. Li Q., et al. “Through the Nrf2 protective response in human mesenchymal stem cells, ginger oleoresin reduced reactive oxygen species brought on by gamma-ray irradiation”. Oxidative Medicine and Cellular Longevity (2017): 1480294.
35. Hlavac J., et al. “Effects of quercetin and ginger phenylpropanoids on the Nrf2-ARE pathway in human HaCaT keratinocytes and BJ fibroblasts”. BioMed Research International (2016) 2173275.
36. Yeh H., et al. “Analysis of the bioactive ingredients in two different gingers (Zingiber officinale Roscoe) and the antioxidant properties of ginger extracts”. LWT - Food Science and Technology1 (2014): 329-334.
37. Rhodes CJ., et al. “Focusing on free radicals in human disorders linked to oxidative stress”. Pharmacological Sciences9 (2017): 592-607.
38. Li L., et al. “Antioxidant capabilities and total phenolic contents of infusions made from 223 medicinal herbs”. Industrial Crops and Products 51 (2013): 289-298.
39. Deng G., et al. “The antioxidant capabilities and total phenolic contents of 56 vegetables”. Journal of Functional Foods2 (2013): 260-266.
40. Deng G., et al. “The determination of antioxidant properties and their hydrophilic and lipophilic phenolic contents in cereal grains”. Journal of Functional Foods 4 (2012): 906-914.
41. Xu B., et al. “Herbal and tea infusions' total phenolic contents and antioxidant potential”. International Journal of Molecular Sciences4 (2011): 2112-2124.
42. Fu L., et al. “The antioxidant capabilities and total phenolic contents of 62 fruits”. Food Chemistry1 (2011): 345-350.
43. Guo Y., et al. “49 edible macrofungi's polysaccharide, phenolic component, and antioxidant capabilities”. Food Function10 (2012): 1195-1205.
44. Song F., et al. “Antioxidant potential and total phenolic content of a few chosen Chinese medicinal herbs”. International Journal of Molecular Sciences6 (2010): 2362-2372.
45. Abolaji AO., et al. “Protective effects of 6-gingerol-rich fraction from Zingiber officinale (ginger) on oxidative damage and inflammation caused by chlorpyrifos in rats' brain, ovary, and uterus”. Chemico-Biological Interactions 270 (2017): 15-23
46. Li Y., et al. “Chemical characterisation and comparison of antioxidant activity in carbonized, stir-fried, dried, and fresh ginger”. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 1011 (2016): 223-232.
47. Konczak I., et al. “The polyphenolic-rich portion of commercial dry ginger powder exhibits antioxidative, enzyme-inhibiting, and antiproliferative properties”. International Journal of Food Science and Technology10(2015): 2229-2235.
48. Gunathilake KDPP and Rupasinghe HPV. “In vitro inhibition of human low-density lipoprotein oxidation by ginger extracts”. Journal of Medicinal Food 4(2014): 424-431.
49. Oboh G., et al. “In vitro, aqueous extracts of two types of ginger (Zingiber officinale) prevent lipid peroxidation in the rat heart caused by sodium nitroprusside, iron (II), and the angiotensin I-converting enzyme”. Journal of Medicinal Food7 (2013): 641-646.
50. Bagheri A., et al. “Ginger (Zingiber officinale Roscoe) extract protects cultured chondrocytes from interleukin-1 beta-induced mitochondrial apoptosis and oxidative stress”. Organs, Tissues, and Cells 204 (2017): 241-250.
51. Romero A., et al. “Ginger extract's impact on AKT activation and membrane potential alterations in a peroxide-induced oxidative stress cell model”. King Saud University Science Journal 2 (2018): 263-269.
52. Muhammadi F., et al. “Zingiber officinale extract protected the rat testis following cyclophosphamide treatment”. Andrologia6 (2014): 680-686.

Citation

Citation: Firoj A Tamboli., et al. “Exploring Nutritional Phytochemicals in Medicinal Plants for UV Protection".Acta Scientific Nutritional Health 9.7 (2025): 62-71.

Copyright

Copyright: © 2025 Firoj A Tamboli., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.