Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Review Article Volume 7 Issue 8

Solubilization of Carbon 60 in a Non-Toxic Solvent and Opportunities for Medical Development

Leonard W Heflich*

Innovation for Success, USA

*Corresponding Author: Leonard W Heflich, Innovation for Success, USA.

Received: July 05, 2023; Published: July 25, 2023


We are reporting a breakthrough in the solubilization of Carbon 60 crystals using a non-toxic, non-polar solvent which enables for the first time the development of functional products containing C60 at effective concentrations. Over one hundred human conditions and diseases have been linked to the excess production of free radical molecules [1]. A solubilized C60 is uniquely capable of diffusing into cells and mitochondria to neutralize dangerous free radical molecules that cause damage to proteins, fats and DNA, resulting in disease. This innovation opens to doors to many opportunities to apply C60 to prevent or stop disease including cancer, autoimmune diseases, the Cytokine Storm as occurs in COVID and influenza infections, inflammatory conditions, radiation and sunburn.

Keywords: Solubilization; Carbon 60; Solvent


  1. Ak Tuba. “Antioxidant and Radical Scavenging Properties of Curcumin”. Chemico-Biological Interactions 174 (2008): 27-37.
  2. Kroto Harold. “The First Predictions in the Buckminsterfullerenes Crystal Ball”. Fullerene Science and Technology4 (1994): 333-342.
  3. Osawa E. “The Evolution of the Football Structure for the C60 Molecule: A Retrospective and Discussion”. Philosophical Transactions Royal Society London 343 (1993): 1-8.
  4. Foley Sarah. “Cellular Localisation of a Water-Soluble Fullerene Derivative”. Biochemical and Biophysical Research Communications1 (2002): 116-119.
  5. Bakry Rania. “Medicinal Applications of Fullerenes”. International Journal of Nanomedicine4 (2007): 639-49.
  6. Markovic Zoran and Vladimir Trajkovic. “Biomedical Potential of the Reactive Oxygen Species generation and Quenching by Fullerenes (C60)”. Biomaterials 29 (2008): 3561-3573.
  7. Srivastava Ambrish Kumar. “C60 as Electron Acceptor and Donor: A Comparative DFT Study of Li@C60 and F@C60”. Australian Journal of Chemistry 71 (2018): 953-956.
  8. Anilkumar P. “Fullerenes for Applications in Biology and Medicine”. Current Medicinal Chemistry14 (2011): 2045-2059.
  9. Guan Wen-chao. “Protective Effect of Reduced Glutathione C60 Derivative against Hydrogen Peroxide-Induced Apoptosis in HEK 293T Cells”. Huazhong University of Science and Technology 3 (2016): 356-363.
  10. Tachikawa Hiroto. “DFT Study Onthe Interaction of Fullerene (C60) with Hydroxyl Radical (OH)”. Physics Procedia 14 (2011): 139-142.
  11. Sergeeva Vasilina. “Antioxidant Properties of Fullerene Derivatives Depend on Their Chemical Structure: A Study of Two Fullerene Derivatives on HELFs”. Oxidative Medicine and Cellular Longevity 4398695 (2019).
  12. “Fullerene C60 PubChem CID 123591”. PubChem, Compound Summary for CID 123591 (2019).
  13. “Particle Size Analysis of Vitamins”. Horiba Scientific
  14. Slominski Andrzej T. “Melatonin, Mitochondria and the Skin”. Cellular and Molecular Life Sciences 74 (2017): 3913-3925.
  15. Tan Dun-Xian. “Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism”. Molecules 20 (2015): 18886-18906.
  16. VA Chistyakov., et al. “Possible Mechanisms of Fullerene C60 Antioxidant Action”. BioMed Research International (2013).
  17. Hansen Charles M. “Using Hansen Solubility Parameters to Correlate Solubility of C60 Fullerene in Organic Solvents and in Polymers”. Carbon8-9 (2004): 1591-1597.
  18. Marcus Yizhak. “Solubility of C60 Fullerene”. Journal of Physical Chemistry B13 (2001): 2499-2506.
  19. Törpe Alexander. “Improved Spectrophotometric Analysis of Fullerenes C60 and C70 in High-Solubility Organic Solvents”. Analytical Sciences 31 (2015): 125-30.
  20. Saraswati Teguh Endah. “The Study of Optical Properties of C60 Fullerene in Different Organic Solvents”. Open Chemistry 17 (2019): 1198-1212.
  21. Liu Huanxiang. “Accurate Quantitative Structure-Property Relationship Model to Predict the Solubility of C60 in Various Solvents Based on a Novel Approach Using a Least-Squares Support Vector Machine”. Journal of Physical Chemistry B43 (2005): 20565-20571.
  22. Xiaobing Hu. “TEM Image of Dissolved C60”. NUANCE TEM Facility Personal Communication (2021).
  23. Muriel Pablo. “Role of Free Radicals in Liver Disease”. Hepatol Int3 (2009): 526-536.
  24. Manibusan Mary K. “Postulated Carbon Tetrachloride Mode of Action: A Review”. Journal of Environmental Science and Health, Part C3 (2007): 185-209.
  25. Durasevic Sinisa. “Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes”. Antioxidants911 (2021): 1-19.
  26. Rezacova Martina. “Fullerene Nano Particles and Their Anti-Oxidative Effects: A Comparison to Other Radio Protective Agents”. Journal of Applied Biomedicine (2012).
  27. Vavrova Jirina. “Fullerene Nanoparticles and Their Anti-Oxidative Effects: A Comparison to Other Radioprotective Agents”. Journal of Applied Biomedicine1 (2012): 1-8.
  28. Andrievsky Grigory V. “Peculiarities of the Antioxidant and Radioprotective Effects of Hydrated C60 Fullerene Nanostructures in Vitro and in Vivo”. Free Radical Biology and Medicine6 (2009): 786-793.
  29. Kato Shinya. “Defensive Effects of Fullerene-C60/Liposome Complex against UVA-Induced Intracellular Reactive Oxygen Species Generation and Cell Death in Human Skin Keratinocytes HaCaT, Associated with Intracellular Uptake and Extracellular Excretion of Fullerene-C60”. Journal of Photochemistry and Photobiology B: Biology 98(2010): 144-151.
  30. Kato Shinya. “Fullerene-C60/Liposome Complex: Defensive Effects against UVA-Induced Damages in Skin Structure, Nucleus and Collagen Type I/IV Fibrils, and the Permeability into Human Skin Tissue”. Journal of Photochemistry and Photobiology B: Biology 98 (2010): 99-105.
  31. Mousavi S Zeinab. “Fullerene Nanoparticle in Dermatological and Cosmetic Applications”. Nanomedicine: Nanotechnology, Biology and Medicine3 (2017): 1071-1087.
  32. Krusic PJ. “Radical Reactions of C60”. Science5035 (1991): 1183-1185.
  33. Lin Qianyu. “UV Protection and Antioxidant Activity of Nanodiamonds and Fullerenes for Sunscreen Formulations”. Applied Nanomaterials12 (2019): 7604-7616.
  34. Alperovich IG., et al. “Fullerenes as Anti-Aging Antioxidants”. Current Aging Science (2016).
  35. Baati Tarek., et al. “The Prolongation of the Lifespan of Rats by Repeated Oral Administration of [60] Fullerene”. Biomaterials (2012): 1-11.
  36. Shytikov Dmytro. “Effect of Long-Term Treatment with C60 Fullerenes on the Lifespan and Health Status of CBA/Ca Mice”. Rejuvenation Research (2021).
  37. Turner Ashley R. “Studies Examining the Anti-Aging Effects of Fullerenes”. Dissertation Submitted to the Graduate School at the University of North Carolina at Greensboro (2017).
  38. Hirai Toshiro. “Potential Suppressive Effects of Two C60 Fullerene Derivatives on Acquired Immunity”. Nanoscale Research Letters 11 (2016): 449.
  39. Shershakova Nedezda., et al. “Anti-Inflammatory Effect of Fullerene C60 in a Mice Model of Atopic Dermatitis”. Journal of Nanobiotechnology 14 (2016).
  40. Ryan John J., et al. “Fullerene Nanomaterials Inhibit the Allergic Response”. The Journal of Immunology 179 (2007): 665-672.
  41. Hans Mayank. “Toll-like Receptors and Their Dual Role in Periodontitis: A Review”. Journal of Oral Science3 (2011): 263-271.
  42. Liu Qihai. “The Applications of Buckerminsterfullerene C60 and Derivatives in Orthopaedic Research”. Connective Tissue Research 2 (2014): 71-79.
  43. Bouziat Romain. “Reovirus Infection Triggers Inflammatory Responses to Dietary Antigens and Development of Celiac Disease”. Science6333 (2017).
  44. Oyinloye Babatunji Emmanuel. “Reactive Oxygen Species, Apoptosis, Antimicrobial Peptides and Human Inflammatory Diseases”. Pharmaceuticals8 (2015): 151-175.


Citation: Leonard W Heflich. “Solubilization of Carbon 60 in a Non-Toxic Solvent and Opportunities for Medical Development".Acta Scientific Nutritional Health 7.8 (2023): 93-96.


Copyright: © 2023 Leonard W Heflich. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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