Nur Khairina Binte Azan^1,2, Ariel SY Ng^1,2, Farij Bin Samsudi^1,2, Muhammad Rusydi Bin Mazlan^1,2, Yuan Kai Loh^1,2 and Maurice HT Ling^1,2,3,4*

¹School of Life Sciences, Management Development Institute of Singapore, Singapore
²Department of Life Sciences, University of Roehampton, United Kingdom
³School of Data Sciences, Perdana University, Malaysia
⁴HOHY PTE LTD, Singapore

*Corresponding Author: Maurice HT Ling, School of Life Sciences, Management Development Institute of Singapore, Singapore.

Received: January 02, 2023; Published: January 19, 2023

Abstract

Alzheimer’s disease (AD) is an age-related neuronal disorder characterized by abnormal levels of proteins, beta amyloid (Aβ) and tau, resulting in gradual loss of cognitive functions due to impaired network of neurons in the brain. Past literature has proposed dietary interventions through administration of Mediterranean Diet (MD) as a solution to prevent AD development. A systematic review on the effectiveness of MD in preventing AD is executed up to July 3, 2022, using PubMed as source database within the last 5 years between 2018 to 2022. 131 articles were identified, and 26 articles were included in this review. After analysing the articles, 5 themes were identified to examine the effectiveness of MD: namely, (a) MD adherence and AD risk (b) MD and AD pathological development, (c) MD and cognitive health (d) Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, and (e) Diet-microbe interaction. MD adherence is a vital factor in achieving successful dietary intervention. Various covariates and demographics affect adherence level. Differing evidence from literature discuss MD’s efficacy in preventing AD. MD is concluded to be effective to a certain extent in preventing Alzheimer’s disease due to various factors such as adherence levels, demographics etc and further longitudinal and randomised control trials (RCT) are warranted.

Keywords: Randomised Control Trials (RCT); Alzheimer’s Disease (AD); Mediterranean Diet

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Citation

Citation: Maurice HT Ling., et al. “A 5-Year Systematic Review (2018 to 2022) on The Effectiveness of Mediterranean Diet in Preventing Alzheimer’s Disease". Acta Scientific Nutritional Health 7.2 (2023): 79-90.

Copyright

Copyright: © 2022 Maurice HT Ling., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.