Abstract

Introduction: We aim to investigate the longitudinal associations between level of physical activity (PA) and the risk of mild cognitive impairment (MCI) and dementia among type 2 diabetes (T2D) and pre-diabetes (PD) participants who are cognitively normal at study entry.

Methods: We used data from the Age-Gene/Environment-Susceptibility-Reykjavik-Study (65-96 years). From the original sample, 3001 participants with a complete evaluation of T2D, MCI and dementia were included in this analysis.

Results: During follow-up (5.2 years), 8.5% (n = 256) developed MCI and 3.7% (n = 111) developed dementia. T2D participants had an increased risk for MCI (OR = 1.632, P = 0.021) and both PD and T2D individuals had increased risk for dementia (OR = 1.947, P = 0.003 and OR=2.101, P = 0.026). PA was associated with lower dementia risk in normal participants only (OR = 0.611, P = 0.019).

Discussion: Older adults with PD/T2D had low level of PA and higher risk of declining cognitive function.

Keywords: Type 2 Diabetes; Mild Cognitive Impairment; Dementia; Physical Activity; Glucose Regulations

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Citation

Citation: Eymundsdottir H., et al. “Type 2 Diabetes, Physical Activity and Risk of Mild Cognitive Impairment and Dementia in Community Dwelling Old Adults".Acta Scientific Nutritional Health 5.11 (2021): 59-66.

Copyright

Copyright: © 2021 Eymundsdottir H., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.