Abstract

  Natural products emerge as a valuable and affordable source for potential drugs which may be used as lead for treatment of many diseases. Using both in vitro and in vivo models, Badria and his team were able to find different natural products with superb biological activities.Liver fibrosis represents a major health burden and is one of the most common causes of death worldwide. The possible hepatoprotective effect of methanolic extract of Saussurea lappa (Sl) root was investigated against CCl4-induced liver fibrosis in rats. Intraperitoneal injection of 50% CCl4 (1ml/kg) twice weekly for 8 weeks, significantly raised the levels of serum ALT, AST, liver MDA and percentage of collagen area and significantly decreased liver GSH as compared to the control group fed on basal diet only. Administration of Sl root extract to the rats in a daily dose of 400 mg/kg, concomitantly with CCl4, significantly prevented the CCl4-induced rise in plasma levels of ALT, AST, liver MDA and percentage of collagen area and increased liver GSH as compared to the CCl4-treated group. Moreover, liver histopathology in Sl-treated group showed relatively preserved architecture, less inflammatory cellular infiltration, less collagen deposition with less positive reaction in immunohistochemical staining for α-SMA, as compared to CCl4-treated group. These results explained the preventive effect of Sl root extract on liver fibrosis in rats, through antioxidant, anti- inflammatory activities and through prevention of hepatic stellate cell activation.

Keywords: Antifibrotic; Saussurea lappa; CCl4; Liver Fibrosis

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Citation

Citation: Farid A Badria., et al. “Antifibrotic Activity of Saussurea lappa Root Extract on CCl4-induced Liver Fibrosis in Rats". Acta Scientific Nutritional Health 4.2 (2020): 67-70.

Copyright

Copyright: © 2020 Farid A Badria., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.