Several landmark discoveries have deepened our understanding of living organisms, for example the structure of the cell, the role of organelles, and the mechanisms of protein synthesis. Recent food and health metabolomic research has gone one step beyond classical nutrient-based concepts of nutrition, approaching the essence of biology. So far, we have delved into the cause of diseases at the genome and epigenome level. A further step is the discovery of microRNAs (miRNA), and their importance in controlling health and diseases [1-4]. We are thus closer to understanding the mysteries of life.

References

1. Lee RC., et al. “Elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14”. Cell5 (1993): 843–854.
2. Bartel DP. “MicroRNAs: genomics, biogenesis, mechanism, and function”. Cell2 (2004): 281–297.
3. Friedman RC., et al. “Most mammalian mRNAs are conserved targets of microRNAs”. Genome Research 1 (2009): 92–105.
4. Ambros V. “The functions of animal microRNAs”. Nature7006 (2004): 350–355.
5. Axtell MJ and Bartel DP. “Antiquity of microRNAs and their targets in land plants”. The Plant Cell6 (2005): 1658–1673.
6. Axtell MJ., et al. “Vive la différence: biogenesis and evolution of microRNAs in plants and animals”. Genome Biology 12 .4 (2011): 221.
7. Lelandais-Brière C., et al. “Small RNA diversity in plants and its impact in development”. Current Genomics 11 .1 (2010): 14–23.
8. Heimberg AM., et al. “MicroRNAs and the advent of vertebrate morphological complexity”. Proceedings of the National Academy of Sciences of the United States of America8 (2008): 2946–2950.
9. Salmena L., et al. “A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?”. Cell 146 .3 (2011): 353–358.
10. Kakimoto Y., et al. “MicroRNA Stability in FFPE Tissue Samples: Dependence on GC Content”. PLoS One9 (2016): e0163125.
11. Kakimoto Y., et al. “MicroRNA deep sequencing reveals chamber-specific miR-208 family expression patterns in the human heart”. International Journal of Cardiology 211 (2016): 43-48.
12. Boeckel JN., et al. “From heart to toe: heart's contribution on peripheral microRNA levels”. International Journal of Cardiology3 (2014): 616–617.
13. Phua YL., et al. “Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival”. Physiological Reports10 (2015): e12537.
14. Maes OC., et al. “MicroRNA: Implications for Alzheimer Disease and other Human CNS Disorders”. Current Genomics3 (2009): 154–168.
15. Ochiai T and Yamamoto Y. “Development of micro RNA research”. Igaku-no-Ayumi Tokyo (2019).

Citation

Citation: Shaw Watanabe. “MicroRNA Opens up a New World for Nutrition Research".Acta Scientific Nutritional Health 4.1 (2020): 38-39.

Copyright

Copyright: © 2020 Shaw Watanabe. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.