Acta Scientific Nutritional Health

Research ArticleVolume 2 Issue 7

Weight Loss Associated with High Protein Diet Intake in Obesity: Interactions of Gut Microbiota in Protein Sources Influencing this Positive Effect

Kulvinder Kochar Kaur1*, Gautam Allahbadia2 and Mandeep Singh3

1Kulvinder Kaur Centre for Human Reproduction, Punjab, India
2Rotunda-A Centre for Human Reproduction, Mumbai, India
3Consultant Neurologist, Swami Satyanand Hospital, Near Nawi Kachehri, Baradri, Punjab, India

*Corresponding Author: Kulvinder Kochar Kaur, Kulvinder Kaur Centre for Human Reproduction, Punjab, India.

Received: May 10, 2018; Published: June 25, 2018

Citation: Kulvinder Kochar Kaur., et al. “Weight Loss Associated with High Protein Diet Intake in Obesity: Interactions of Gut Microbiota in Protein Sources Influencing this Positive Effect”. Acta Scientific Nutritional Health 2.7 (2018).


  It has been known for some time that high protein diet prevents the development of diet induced obesity and may influence the association of metabolic disorders in mice. Dietary supplementation of various amino acids like leucine can partially mimic this effect. There has been a suggestion that high amino nitrogen intake may possibly lower storage and prevent insulin resistance. Other mechanisms include greater satiating effects of high protein diet as compared to high carbohydrate or high fat diet. This effect on satiety modulation involves multiple metabolic pathways. Protein intake induces signals leading to the release of peptide hormones like GLP-1 and PYY from the gastrointestinal tract. Also, Protein intake stimulates release of metabolic hormones which communicate energy status to the brain. Thus, long term intake of high protein diet seems to decrease food intake, weight and body adiposity in many well conducted studies. These effects are seen in 67% of population only with some gene effects as per the Dio Gene study. Still there had been a skepticism regarding a negative effect on kidney and bone health. In this review we have tried to highlight how it is not only protein per se but the additional components of nutrients which is contained in protein containing foods which influence the weight lowering ability of proteins, besides interfering with alterations in gut microbiota, which is already known as a well-known factor in influencing obesity development. Milk, dairy products have been found to be beneficial, contrary to lay press and social media belief that they need to be replaced by plant-based drinks.

Keywords: High Protein Diet; Leucine; Satiety; GLP1; PYY; Gut Microbiota; High Amino Nitrogen Intake

Copyright: © 2018 Kulvinder Kochar Kaur., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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