Lutfat Abimbola Usman* and Emmanuel Oladipo Ajani

Department of Biochemistry, Kwara State University, Malete, PMB 1530, Ilorin 241104, Nigeria

*Corresponding Author: Lutfat Abimbola Usman, Department of Biochemistry, Kwara State University, Malete, PMB 1530, Ilorin 241104, Nigeria.

Received: July 30, 2025; Published: August 30, 2025

Abstract

Neurodegenerative diseases, characterized by neuroinflammation, pose significant global health challenges, exacerbated by environmental toxins like acrylonitrile (AN). This study investigates the anti-inflammatory potential of Tamarindus indica fruit pulp ethanolic extract in an AN-induced neuroinflammation model in male Wistar rats. Seventy rats were divided into seven groups, receiving varying doses of T. indica extract (200 or 400 mg/kg body weight) either preventively or therapeutically alongside AN exposure, with normal and positive controls. Brain homogenates were analyzed for pro-inflammatory cytokines (IL-6, IL-1β, and TNF-α) using ELISA techniques. Results revealed significant reductions in cytokine levels in both preventive and treatment groups compared to the negative control, with the lowest IL-6 levels in the high-dose treatment group (4.899 ± 0.023 pg/mL) and the lowest IL-1β and TNF-α levels in the low-dose preventive group. These findings suggest that T. indica extract effectively mitigates AN-induced neuroinflammation, likely through modulation of inflammatory pathways, highlighting its potential as a cost-effective, natural therapeutic for neurodegenerative diseases.

Keywords: Neuroinflammation; Tamarindus indica; Acrylonitrile; Pro-Inflammatory Cytokines; Neurodegenerative Diseases

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Citation

Citation: Lutfat Abimbola Usman and Emmanuel Oladipo Ajani. “Neuroprotective Potential of Tamarindus indica Fruit Pulp Extract Against Acrylonitrile-Induced Neuroinflammation in Male Albino Rats".Acta Scientific Veterinary Sciences 7.9 (2025): 48-53.

Copyright

Copyright: © 2025 Lutfat Abimbola Usman and Emmanuel Oladipo Ajani. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.