Pragati P Gurav¹*,Abhishek Pal², Mitali V Dalvi³, Tejas Jain⁴, Shubham H Dhavale⁵, Satyam R Pokale⁶, Aniket G Dhanure⁶, Payal S Raykar⁶ and Abhee V Balapure⁶

¹Assistant Professor of MGM School of Pharmacy, Kamothe, Navi Mumbai, India
²Senior Scientific Assistant, Zydus Research Centre, India
³Assistant Professor of Swami Institute of Pharmacy, Abhona, India
⁴Student of MSc Pharmacology and Drug Discovery, University - Coventry University
⁵Students of Krishnarao Bhegade Institute of Pharmaceutical and Education Research, Talegaon Dabhade
⁶Student of Sinhgad College of Pharmacy, Vadgaon Bk. Pune, India

*Corresponding Author: Pragati P Gurav, Assistant Professor of MGM School of Pharmacy, Kamothe, Navi Mumbai, India.

Received: May 06, 2025; Published: June 23, 2025

Abstract

Cardiovascular diseases (CVDs) comprise disorders of the heart and blood vessels and still represent a major cause of death globally. CVDs have shown to be responsible for approximately 17.9 million deaths each year, which accounts for 31% of all deaths worldwide. Among the various CVDs, myocardial infarction (MI) is a major cause of mortality and morbidity across the world. The different doses of Apium Graveolens (100, 200, and 400 mg/kg) and metoprolol (10 mg/kg) were calculated based on the animal’s body weight were administered per oral for 30 days. Parameter for assessment of the effect of Apium Graveolens isoproterenol-induced cardiomyopathy in rats: Body weight, Electrocardiographic, Hemodynamic , Heart Weight, Heart/Body Weight, CKMB, LDH, ALP ,Anti-oxidant activity (Total protein, MDA, nitric oxide, GSH and SOD) in cardiac tissue, Histopathology of cardiac tissue. treatment with metoprolol (10 mg/kg) significantly (P < 0.001) decreased RR interval as compared to vehicle control rats. Treatment with BS (100 and 200 mg/kg) showed a significant and dose dependent (P < 0.01 and P < 0.001) decreased in RR interval as compared to vehicle control rats.

Keywords: Cardioprotective Activity; Apium Graveolens; Myocardial Toxicity

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Citation

Citation: Pragati P Gurav., et al. “Cardioprotective Efficacy of Standardized Extract of Apium Graveolens Against Isoproterenol-Induced Myocardial Toxicity in Rats".Acta Scientific Veterinary Sciences 7.7 (2025): 18-35.

Copyright

Copyright: © 2025 Pragati P Gurav., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.