Panashe Trinity Mundandishe^1,2*, Silvester Maravanyika Chikerema¹, Kudzai Mupondi¹, Orgies Kudzai Mapurisa¹, Columbus Chaitezvi¹ and Musavengana Tivapasi³

¹Scientific Services, Zimbabwe Parks and Wildlife Authority, Harare, Zimbabwe
²African Parks Foundation, Tashinga Headquarters, Matusadonha National Park, Zimbabwe
³Department of Clinical Veterinary Sciences, University of Zimbabwe, Harare, Zimbabwe

*Corresponding Author: Panashe Trinity Mundandishe, Scientific Services, Zimbabwe Parks and Wildlife Authority, African Parks Foundation, Tashinga Headquarters, Matusadonha National Park, Zimbabwe.

Received: May 19, 2025; Published: June 18, 2025

Abstract

The report is about a case of a female 3½-year-old African wild dog with a pedunculated mass on ventral cervical region. The dog was immobilized using a combination of ketamine (5mg/kg) and medetomidine (0.1mg/kg). Blood samples were collected for FBC and biochemistry, and an excision biopsy was performed on the lesion. Hematology results showed an increased erythron, consistent with relative polycythaemia. The leukogram showed moderate lymphocytosis with neutrophils and monocytes on the upper limit consistent with mild to moderate chronic inflammation. Histology sections showed round cells with hyperchromatic nuclei with course chromatin, and moderate to abundant lightly basophilic, granular cytoplasm. The cells tended to form sheets or linear cords with low mitotic index, suggestive of a low-grade mast cell tumour. The dog was however, lost from the pack before surgical intervention could be performed. The report highlights the dearth of data on wild dog neoplasms and emphasizes the need for more surveillance on diseases affecting African wildlife species under threat.

Keywords: Mast Cell Tumour; African Wild Dog; Neoplasms

References

1. Giraudeau M., et al. “Approaches and methods to study wildlife cancer”. Journal of Animal Ecology. 93.10 (2023): 1410-1428.
2. Meirelles AEWB., et al. “Prevalence of cutaneous neoplasms in dogs from the metropolitan area of Porto Alegre, RS, Brazil: 1,017 cases (2002-2007)”. Brazilian Journal of Veterinary Research 30 (2010): 968-973.
3. Tamlin V., et al. “Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment”. Veterinary Medicine and Science1 (2020): 3-18.
4. Pierini A., et al. “Epidemiology of Breed-Related Mast Cell Tumour Occurrence and Prognostic Significance of Clinical Features in a Defined Population of Dogs in West-Central Italy”. Veterinary Science 6 (2019): 53.
5. Cavalcante IM., et al. “A retrospective study of canine cutaneous mast cell tumour: correlation between clinical, histological and molecular characteristics”. Brazilian Journal of Development 12 (2020): 100281-100299.
6. Nardi AB., et al. “Diagnosis, Prognosis and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumours”. Cells 11 (2022): 618.
7. Webster JD., et al. “Cellular Proliferation in Canine Cutaneous Mast Cell Tumors: Associations with c-KIT and Its Role in Prognostication”. Veterinary Patholology 44 (2007): 298-308.
8. Smiech A., et al. “Occurrence and distribution of canine cutaneous mast cell tumour characteristics among predisposed breeds”. Journal of Veterinary Research 63 (2019): 141-148.
9. Kiupel M., et al. “Proposal of a 2-Tier Histologic Grading System for Canine Cutaneous Mast Cell Tumors to More Accurately Predict Biological Behavior”. Veterinary Pathology 48 (2010): 147-155.
10. Dennis A., et al. “Epidemiology of Canine Mast Cell Tumours in Uruguay”. Brazilian Journal of Veterinary Pathology 3 (2020) 581-584.
11. Santos DO., et al. “Cutaneous mast cell tumor in a captive Bush dog (Speothos venaticus): pathological and immunophenotypical aspects – case report”. Brazilian Journal of Veterinary and Animal Science 5 (2021): 1099-1104.
12. Onkels AK., et al. “Multiple cutaneous mast cell tumours in a Boa imperator”. Veterinary Record Case Reports 1 (2020) 1-4.v
13. Seguel M., et al. “Pulmonary Mast cell Tumour and Possible Paraganglioma in a Free-ranging Pacific Walrus (Odebenus rosmarus divergens), Barrow, Alaska, USA”. Journal of Wildlife Diseases 52 (2016): 407-410.
14. Campbell-Ward MI., et al. “Mast Cell Tumours in Cheetah (Acinonyx jubatus): A Case Series”. Journal of Zoo and Wildlife Medicine4 (2021): 1025-1034.
15. Mullins MN., et al. “Evaluation of prognostic factors associated with outcome in dogs with multiple cutaneous mast cell tumours treated with surgery with and without adjuvant treatment: 54 cases (1998-2004)”. Journal of the American Veterinary Medical Association 228 (2006): 91-95.
16. Lejeune A., et al. “Aggressive local therapy combined with systemic chemotherapy provides long-term control in grade ii stage 2 canine mast cell tumour: 21 cases, (1999-2012)”. Veterinary Comparative Oncology 13 (2013): 267-280.
17. Madsen T., et al. “Cancer Prevalence and Etiology in Wild and Captive Animals. Editors: Uvjari B, Thomas F, in: Ecology and Evolution of Cancer” (2017): 11-46.
18. Vittecoq M., et al. “Cancer: A missing link in ecosystem functioning?” Trends in Ecology and Evolution 28 (2013) 628-635.

Citation

Citation: Panashe Trinity Mundandishe., et al. “Mast Cell Tumour in an African Wild Dog (Lycaon pictus)".Acta Scientific Veterinary Sciences 7.7 (2025): 09-13.

Copyright

Copyright: © 2025 Panashe Trinity Mundandishe., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.