Abiodun Temitayo Wahab^1,2* and Matthew Olugbenga Oyeyemi¹

¹Department of Theriogenology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria
²Centre for Convergent Bioscience and Medicine, The University of Alabama, U.S.A

*Corresponding Author: Abiodun Temitayo Wahab, Centre for Convergent Bioscience and Medicine, Address: The University of Alabama, U.S.A.

Received: November 18, 2024; Published: January 30, 2025

Abstract

Environmental exposure to sodium fluoride (NaF) is a growing concern due to its adverse effects on reproductive health. In this study we investigated the reproductive effects of sodium fluoride and the therapeutic potential of zinc sulfate in male albino rats. Twenty male albino rats were divided into four groups of five animals each; Group A (healthy control) received distilled water, Group B received 50mg/kg Zinc Sulfate, group C received 50mg/kg Sodium fluoride and group D received concurrent administration of Sodium fluoride and Zinc Sulfate at 50mg/kg each. Treatments were administered orally for 28 consecutive days after which the rats were euthanized for sample collection and analysis. The collected data were subjected to analysis using descriptive statistics and ANOVA with GraphPad Prism version 5.0. The findings from this study concluded that the sodium fluoride (NaF) has significant effect on hematology, serum chemistry, semen quality, testosterone levels, and testicular architecture whilst the administration of zinc sulfate (ZnSO4) was effective in ameliorating the toxic effects induced by NaF on blood parameters, serum chemistry, and the histopathological damage in the testes.

 Keywords: Sodium Fluoride; Zinc Sulfate; Male Wistar Rats; Testicular Degeneration

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Citation

Citation: Abiodun Temitayo Wahab and Matthew Olugbenga Oyeyemi. “Zinc Sulfate Ameliorates Testicular Degeneration Induced by Sodium Flouride in Male Wistar Rats". Acta Scientific Veterinary Sciences 7.2 (2025): 23-32.

Copyright

Copyright: © 2025 Abiodun Temitayo Wahab and Matthew Olugbenga Oyeyemi. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.