Possible Metabolic Alteration and Endocrinological Dysregulation in Canine Chronic Kidney
Disease with Renal Osteodystrophy: A Comprehensive Review
Alok Kumar Chaudhary*
Department of Veterinary Medicine, College of Veterinary and Animal Sciences,
DUVASU Mathura, U.P., India
*Corresponding Author: Alok Kumar Chaudhary, Assistant Professor
Department of Veterinary Medicine, College of Veterinary and Animal Sciences, DUVASU Mathura, U.P., India.
Received:
March 05, 2024Published: March 26, 2024
Abstract
Chronic kidney disease (CKD) in dogs is associated with metabolic alterations and endocrinological dysregulation that can lead to renal osteodystrophy syndrome. This review article examines the complex abnormal signaling and interactions between circulating minerals, vitamins, hormones, cytokines, and fibroblast growth factor during CKD. Despite recent advances, the pathogenesis of renal osteodystrophy in CKD dogs remains unclear. This article includes recently published research and insights from authors to enhance our understanding of the basic mechanisms of kidney regulation and dysregulation in CKD dogs.
Keywords: CKD; Signalling; Calcium; Osteodystrophy; PTH
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