Beenu Jain¹*, Anuj Tewari², Surender Kumar Kadian¹

¹Department of Veterinary Microbiology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, India
²Department of Veterinary Microbiology, College of Veterinary and Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India

*Corresponding Author: Beenu Jain, Department of Veterinary Microbiology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, India.

Received: January 24, 2022; Published: January 31, 2022

Abstract

In endemic countries FMD outbreaks are controlled by vaccinating the animals by using a trivalent FMD vaccine. The aim of this study was to compare the avidity of antibodies developed against O and Asia 1 FMDV serotypes in multiple vaccinated animals against FMD. In this study, thirty-three serum samples from multiple vaccinated animals, against Foot-and-mouth disease (FMD) were collected from field buffaloes. Samples with titre more than 1.4 in LPBE were selected for measuring antibody avidity. The study was conducted to know the post vaccination avidity index of antibodies against O and Asia 1 serotype of FMDV. For this purpose, thirty three serum samples from multiple FMD vaccinated animals were tested by O and Asia 1 serotype specific indirect avidity ELISA. It was found that not all samples having high avidity antibodies for O serotype had high avidity antibodies for Asia 1 serotype. Similarly, not all samples having high avidity antibodies for Asia 1 serotype had high avidity antibodies for O serotype. However, no significant difference was observed in the mean avidity indices of antibodies for both O and Asia 1 serotype. As the avidity indices of antibodies may differ against different serotypes in an individual animal, hence, it is paramount to conduct regular post vaccination monitoring using avidity ELISA.

Keywords: Avidity ELISA; Foot-and-Mouth Disease; High Avidity Index; Post-Vaccination Monitoring

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Citation

Citation: Beenu Jain., et al. “Serotype Specific Antibody Avidity in Multiple Vaccinated Animals Against Foot-and-Mouth Disease". Acta Scientific Veterinary Sciences 4.2 (2022): 96-100.

Copyright

Copyright: © 2022 Beenu Jain., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.