Abstract

  The purpose of this study was to prove the conserved ovine tunica albuginea (OTA) as a practicable and adequate biomaterial for bladder scaffolds even as its histopathological cicatrization aspects. The conserved heterologous OTA implant was experimentally used for cystoplasty in 20 Wistar rats. The operated bladder areas of all rats from test (n = 20) and simulation (n = 20) groups were examined macroscopically and histologically at 7, 14, 2, 8 and 42 postoperative days. Test group animals underwent partial cystectomy followed by cystoplasty with OTA graft application, and simulation group rats to partial cystectomy. There was no mortality in any group, and all animals showed good post-surgery recovery. Bladders histopathological analysis showed that the test group obtained more intensive blood vessels and had the first signs of total regeneration earlier than the simulation group. Our findings pointed that macroscopic and histological results, easiness of surgical technique and graft availability, OTA can be used as an alternative biomaterial graft for bladder wall reconstruction in rats which represent a valuable animal model to comparative studies with the human being and other species.

Keywords:Biomaterials; Bladder; Cystoplasty; Scaffold; Tissue Engineering

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Citation

Citation: Tábata Maués., et al. “Ovine Tunica Albuginea as Xenograft for Cystoplasty in Rats".Acta Scientific Medical Sciences 2.7 (2020): 56-61.

Copyright

Copyright: © 2020 Archana Jain., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.