Ezeibe FI*, Akomas SC and Madubuike KG

Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Nigeria

*Corresponding Author: Ezeibe FI, Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Michael Okpara University of Agricul- ture, Umudike, Nigeria.

Received: April 30, 2026; Published: May 26, 2026

Abstract

Medicinal synthetic aluminum magnesium silicate (MSAMS), a naturally derived nanomaterial, is produced via controlled synthesis from two pharmacopeially recognized silicates: aluminum silicate and magnesium silicate with dextrose monohydrate as a carrier. The parent product, Aluminum magnesium silicate (AMS) is generally regarded as non-absorbable from the gastrointestinal tract and is believed to exert its effects locally but contrary to this facts, AMS in the form of MSAMS can become absorbable from the gastrointestinal tract into systemic circulations. To verify this, 38 six-week old broiler-chicks were drenched with a single dose of MSAMS at 50 mg/kg and two birds were sacrificed post treatment at 120 hours, 240 hours, 360 hours and 480 hours for their livers, brains, kidneys, hearts and skeletal muscles used for tissue-MSAMS concentrations. Means of MSAMS concentrations in brains of broilers at 120, 240, 360 and 480 hours PT (0.72 ± 0.10, 0.52 ± 0.05, 1.39 ± 0.11 & 0.24 ± 0.02) were significantly lower (p > 005) compared to mean concentrations of msams in liver (2.41 ± 0.23, 2.51 ± 0.36, 2.18 ± 0.07 & 2.10 ± 0.20) and muscle tissues (2.41 ± 0.13, 1.14 ± 0.06 1.26 ± 0.06 & 3.04 ± 0.14) at different time interval. The elimination half-lives of MSAMS in the brain (0.026 ± 0.003), liver (1.03 ± 0.28) and muscle (0.21 ± 0.04) were significantly different (p > 0.05) from that in the heart and kidney where their elimination half-lives were not applicable because of negative elimination rate constant, indicating that msams concentration increases over the terminal phase (360-480 hours) in these tissues thus reflecting ongoing tissue uptake or redistribution rather than elimination.

Keywords: MSAMS; Tissues Kinetics; Broilers

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Citation

Citation: “Tissue Kinetics of Medicinal Synthetic Aluminum Magnesium Silicate in Broilers Chicks". Acta Scientific Pharmaceutical Sciences 10.5 (2026): 42-46.

Copyright

Copyright: © 2026 Ezeibe FI., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.