Mukthinuthalapati Mathrusri Annapurna* and Madhuri Potla

Department of Pharmaceutical Analysis, GITAM School of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, India

*Corresponding Author: Mukthinuthalapati Mathrusri Annapurna, Department of Pharmaceutical Analysis, GITAM School of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, India.

Received: November 28, 2025; Published: December 31, 2025

Abstract

Ivacaftor is used for the management of cystic fibrosis. Cystic fibrosis is one of the most common life-threatening autosomal recessive disorders in the Western World. It acts as a Cystic Fibrosis Transmembrane Regulator gene potentiator, enhancing the function of the CFTR gene. A brief review of the analytical techniques such as spectrophotometry, liquid chromatography etc so far developed for the estimation of Ivacaftor were discussed in detail in the present study.

Keywords: Ivacaftor; Lungs; Liquid Chromatography

References

1. Condren ME and Bradshaw MD. “Ivacaftor: a novel gene-based therapeutic approach for cystic fibrosis”. Journal of Pediatric Pharmacology and Therapeutics 18 (2013): 8-13.
2. Kapoor H. “Ivacaftor: a novel mutation modulating drug”. Journal of Clinical and Diagnostic Research 11 (2014): 1-6.
3. Janardhana Reddy., et al. “Method development and validation of Ivacaftor in bulk and pharmaceutical dosage form by UV Spectrophotometry”. International Journal of Research in Pharmaceutical Sciences4 (2018): 1048-1052.
4. Gautam CV., et al. “Method development and validation of ivacaftor in bulk and pharmaceutical dosage form by UV-visible spectrophotometry”. Indo American Journal of Pharmaceutical Science 4 (2019): 7476-7481.
5. Manisha D., et al. “Design and validation of a stability-indicating RP-HPLC technique for quantifying Ivacaftor in bulk and commercial formulations”. Current Pharmaceutical Analysis 21 (2025): 216-224.
6. Roshani Singh., et al. “New cost-effective RP-HPLC method development and validation for quantitative estimation of Ivacaftor in pharmaceutical formulation”. International Journal of Pharmaceutical Sciences Review and Research 1 (2021): 52-57.
7. Saniye Özcan., et al. “Determination of ivacaftor by liquid chromatography techniques in pharmaceutical formulation with interlaboratory comparison and characterization of five novel degradation products by high-performance liquid chromatography ion trap time-of-flight mass spectrometry”. Journal of Separation Science 46 (2023): 2201061.

Citation

Citation: Mukthinuthalapati Mathrusri Annapurna and Madhuri Potla. “A Review on Analytical Techniques for the Ivacaftor". Acta Scientific Pharmaceutical Sciences 10.1 (2026): 69-70.

Copyright

Copyright: © 2026 Mukthinuthalapati Mathrusri Annapurna and Madhuri Potla. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.