Swapnil Deelip Phalak1*, Aasiya Dadel1, Shweta Ravindra Dangat2, Pooja Modhale2 and Akash Sudhakar Ingale3

1Assistant Professor Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute Karjat, India 2Lecturer, Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute Karjat, India 3Assistant Professor, Biyani Pharmacy College, Bhusawal, India

*Corresponding Author:Swapnil Deelip Phalak, Assistant Professor Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute Karjat, India.

Received: December 08, 2025; Published: December 31, 2025

Abstract

Poor aqueous solubility, chemical/enzymatic instability and low bioavailability remain major hurdles for many modern therapeutics (small molecules, peptides, and biologics) [1,2]. Over the last decade the field has advanced rapidly: polymeric nanoparticles (PNPs), lipid-based nanocarriers (including solid lipid nanoparticles, nanostructured lipid carriers, liposomes and modern lipid nanoparticles — LNPs), and hybrid polymer–lipid systems [3-5]. Now offer validated strategies to increase apparent solubility, protect labile drugs, control release, improve mucosal uptake and reduce first-pass loss[6–8]. This review summarizes the recent technological advances (2022–2025), mechanisms by which these nanocarriers boost solubility/stability/bioavailability, formulation and characterization strategies, representative in-vitro/in-vivo outcomes, translational and scale-up considerations, and current challenges/future directions[1,4,5].

Keywords: Polymer; Lipid; Bioavaibility

References

1. Zhang Y and Li X. “Advances in lipid-based nanocarriers for enhancing oral bioavailability”. International Journal of Pharmaceutics 645 (2024): 122123.
2. Patel R and Singh A. “Polymeric nanoparticles for solubility enhancement: a comprehensive review”. Journal of Control Release 355 (2023): 45-62.
3. Kumar P and Yadav V. “Nanostructured lipid carriers for hydrophobic drugs: mechanisms and future perspectives”. Drug Delivery and Translational Research2 (2024): 511-526.
4. Ahmed S and Khan M. “Hybrid polymer-lipid nanoparticles for improved therapeutic delivery”. Materials Science and Engineering C 152 (2023): 113278.
5. Lee H and Choi M. “Microfluidics in nanomedicine: scalable manufacturing of lipid nanoparticles”. Advanced Drug Delivery Reviews 205 (2024): 114223.
6. Gomez R and Alvarez M. “Chitosan-based nanoparticles for mucosal drug delivery”. Carbohydrate Polymer 310 (2023): 120743.
7. Wang J and Zhao Q. “Solid lipid nanoparticles for poorly soluble drugs: recent advancements”. Colloids Surface B Biointerfaces 230 (2024): 113563.
8. Dutta S and Pal A. “Nanocarriers for phytochemical delivery: a systematic review.” Phytomedicine 120 (2023): 155098.
9. Rana M and Tiwari R. “Dendrimers as nanocarriers to enhance aqueous solubility”. Journal of Nanobiotechnology 22 (2024): 45.
10. Huang L and Zhou P. “pH-sensitive polymeric nanoparticles for gastrointestinal stability improvement”. Molecular Pharmaceutics1 (2023): 102-119.
11. Mehta K and Pandey V. “Liposomes in modern drug delivery: trends and challenges”. Journal of Liposome Research2 (2024): 155-175.
12. Silva J and Rocha F. “Biomimetic nanoparticles for enhanced oral absorption of natural compounds”. Nanomedicine7 (2023): 657-674.
13. Irfan M and Shah S. “Lipid nanocarriers for brain targeting: challenges and opportunities”. CNS Drug Delivery3 (2024): 210-229.
14. Okafor N and Eze J. “Nanocrystals vs polymeric nanoparticles: comparative dissolution evaluation”. European Journal of Pharmaceutics and Biopharmaceutics 190 (2023): 45-58.
15. Das R and Sharma M. “Biodegradable nanopolymers for drug stabilization”. Polymer Degradation and Stability 215 (2024): 109403.
16. Torres L and Benitez R. “PEGylated nanoparticles for prolonged systemic circulation”. Journal of Biomed Nanotechnology6 (2023): 1125-1142.
17. Verma A and Gupta N. “Polymeric micelles as platforms for hydrophobic drugs: recent advancements”. Journal of Applied Polymer Science18 (2024): 51678.
18. Park J and Kim D. “Ionizable lipids for advanced LNP design in mRNA therapeutics”. Nanotechnology Review 1 (2024): 20230045.
19. Pandya P and Chauhan H. “Lymphatic uptake via lipid nanocarrier systems”. European Journal of Pharmaceutical Sciences 200 (2024): 106315.
20. Singh R and Kaur P. “Freeze-drying strategies for nanoparticle stabilization”. Journal of Drug Delivery Science and Technology 84 (2023): 104623.
21. Osei K and Mensah D. “Quality-by-design (QbD) approaches in nanoparticle formulation”. International Journal of Nanomedicine 19 (2024): 133-148.
22. Kumar S and Rathore A. “Surfactants in nanocarriers: their role in solubility enhancement”. Journal of Surfactants and Detergents 26 (2023): 411-427.
23. Oliveira T and Santos F. “Nanotechnology approaches to improve permeability of BCS Class III drugs”. Advanced Pharmaceutical Bulletin2 (2024): 255-270.
24. Bhandari P and Khatri N. “Stability testing of nanomedicines: recent advances”. Journal of Pharmaceutical Analysis4 (2023): 312-326.
25. Chung S and Yoon J. “Lipid-polymer hybrid nanocarriers: design and applications”. Acta Biomaterial 168 (2024): 211-233.
26. Frank J and Muller R. “SLNs and NLCs for enhancing oxidative stability of drugs”. Journal of Microencapsulation 3 (2023): 257-276.
27. Zhao Y and Chen H. “Nanoparticle-mediated modulation of P-gp efflux”. Drug Metabolism and Pharmacokinetics 39 (2024): 100-115.
28. Rao S and Menon A. “Analytical characterization tools for nanocarriers”. Analytical and Bioanalytical Chemistry 415 (2023): 7441-7458.
29. Martins M and Costa L. “Nanomedicine regulatory framework: gaps and advancements”. Regulatory Toxicology and Pharmacology 149 (2024): 105399.
30. Ibrahim H, Fahmy A. Stability challenges in polymeric nanocarrier systems”. Journal of Pharmacy and Pharmacology9 (2023): 1123-1140.
31. Ashfaq R., et al. “Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals”. 24.21 (2023): 15764.
32. Mangu K. “Recent advancement in polymeric nanoparticles for oral chemotherapy: Transforming cancer treatment”. Bioimpacts 15 (2025): 31117.
33. Mall J. “Nanostructured lipid carriers as a drug delivery system”. ScienceDirect (2024).
34. Rahat I. “Polymer lipid hybrid nanoparticles for phytochemical delivery”. Beilstein Journal of Nanotechnology (2024).
35. Floyd TG. “Characterisation of polymeric nanoparticles for drug delivery”. RSC Publishing (2025).

Citation

Citation: Swapnil Deelip Phalak., et al. “Complete Review on Advancements in Polymer and Lipid Based Nanoparticles for Enhancing Solubility, Stability and Bioavaibility". Acta Scientific Pharmaceutical Sciences 10.1 (2026): 56-68.

Copyright

Copyright: © 2026 Swapnil Deelip Phalak., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.