Mukthinuthalapati Mathrusri Annapurna* and Sabbarapu Madhuri

GITAM School of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, India

*Corresponding Author: Mukthinuthalapati Mathrusri Annapurna, GITAM School of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, India.

Received: November 28, 2025; Published: December 30, 2025

Abstract

Gadobutrol is a Gadolinium-based contrast agent. Gadolinium-based MRI contrast agents have been widely used in clinical medicine for more than 30 years are all small molecule agents that distribute into all extracellular spaces in tissues without providing any specific biological information. In the present study the authors have summarised the analytical methods so far published for the estimation of Gadobutrol in the literature.

Keywords: Gadobutrol; MRI

References

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2. Malgorzata Kloc., et al. “Gadolinium-based MRI contrast agent effects on calcium signaling and actin-dependent cell functions”. Magnetic Medicine1 (2025): 100004.
3. Ramya Sudha P., et al. “Stability indicating UPLC method for quantitative estimation of Gadobutrol in Gadobutrol solution for intravenous administration”. Journal of Chemical Health Risks6 (2023): 97-106.
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5. Sanni Babu Najana., et al. “On the stability indicating reverse phase high-performance liquid chromatography method for quantitative estimation of impurities in Gadobutrol solution for intravenous administration”. Biosciences Biotechnology Research Communications3 (2022).

Citation

Citation: Mukthinuthalapati Mathrusri Annapurna and Sabbarapu Madhuri. “Analytical Techniques for the Assay of Gadobutrol: A Review". Acta Scientific Pharmaceutical Sciences 10.1 (2026): 48-49.

Copyright

Copyright: © 2026 Mukthinuthalapati Mathrusri Annapurna and Sabbarapu Madhuri. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.