Acta Scientific Pharmaceutical Sciences

Review Article Volume 10 Issue 1

Therapeutic, Pharmacological and Biomedical Uses of Marine and Terrestrial Molluscs: A Review

Kriti Shah and Ravi Kant Upadhyay*

Department of Zoology, D D U Gorakhpur University, Gorakhpur, 273009. U.P. India

*Corresponding Author: Ravi Kant Upadhyay, Department of Zoology, D D U Gorakhpur University, Gorakhpur, 273009. U.P. India.

Received: December 08, 2025; Published: December 22, 2025

Abstract

This review article explains the therapeutic, pharmacological, and biomedical uses of marine and terrestrial molluscs. There are two categories of molluscs: the first one is those that synthesise toxins, and the second is those that inhabit marine algae or protozoans and store. These toxins are used in defence or predation. These toxins pose risks to human health as they impose paralytic (PSP), amnesic (ASP), diarrhetic (DSP), and neurotoxic (NSP) effects. This article sketches out the biological effects of conotoxins, Saxitoxin, Tetrodotoxin, Okadaic acid, Domoic acid (DA) and Brevetoxins (BTXs), Yessotoxin (YTX), Gymnodimine, Neosaxitoxin (NeoSTX), Pectenotoxin (PTX), and dinophysistoxin. These toxins bind to different receptor sites and act in various ways. This article explores the mechanisms of action of marine mollusc toxins, their stability, and their binding to various ion channels. Marine mollusc toxins act more specifically and exhibit anticancer, anti-proliferative, anti-angiogenic, antioxidant, anti-allergic, proteolytic, antidiabetic, antimicrobial, anti-parasitic, and anti-helmintic activities. These are used in cardiovascular diseases and wound healing.

Keywords: Marine Molluscs; Conotoxins; Tetrodotoxins; Proteolytic Activity; Antidiabetic; Antimicrobial; Anti-Parasitic; Anthelmintic Activity

References

  1. Benkendorff, K., et al. “Molluscan biological and chemical diversity: Secondary metabolites and medicinal resources produced by marine molluscs”. Biological Review 85 (2010): 757-775.
  2. Rosenberg, Gary., et al. “A new critical estimate of named species-level diversity of the recent mollusca". American Malacological Bulletin2 (2014): 308-322.
  3. Boulajfene, W., et al. “Nutritional and Health Benefits of Marine Molluscs”. In Marine Biochemistry; Taylor & Francis: Abingdon, UK, (2022): 435-453.
  4. Visciano P., et al. “Marine Biotoxins: Occurrence, Toxicity, Regulatory Limits and Reference Methods”. Frontiers in Microbiology7 (2016): 1051.
  5. Abi-Khalil C., et al. Aquatic Toxicology 190 (2017): 133-141.
  6. Wiese M., et al. “Gene expression and molecular evolution of sxtA4 in a saxitoxin producing dinoflagellate Alexandrium catenella”. Toxicon 92 (2014): 102-112.
  7. Maskrey BH., et al. “Seasonal profile of common pharmaceuticals in edible bivalve molluscs”. Marine Pollution Bulletin 200 (2024): 116128.
  8. Li R., et al. “In Silico Conotoxin Studies: Progress and Prospects”. Molecules24 (2024): 6061.
  9. Le Gall F., et al. “Mental Representation of Knowledge Following Frontal-Lobe Lesion: Dissociations on Tasks Using Scripts”. Journal of Clinical and Experimental Neuropsychology9 (1999): 3134-3142.
  10. Wiese M., et al. “Neurotoxic alkaloids: saxitoxin and its analogs”. Marine Drugs (2010): 2185-2211.
  11. Vilariño N., et al. “Marine Toxins: Unknowns for Optimal Consumer Protection”. Toxins (Basel)8 (2018): 324.
  12. C T Hanifin., et al. “The Chemical and Evolutionary Ecology of Tetrodotoxin (TTX) Toxicity in Terrestrial Vertebrates”. Marine Drugs 8 (2010): 577.
  13. T Noguchi., et al. “Paralytic shellfish poisoning (PSP) toxin- and/or tetrodotoxin-contaminated crabs and food poisoning by them”. Toxin Reviews4 (2011): 91-102.
  14. Timothy A J., Haystead and Alistair T. R. Sim and David Carling and R. C. Honnor and Yasumasa Tsukitani and Patricia T. W. Cohen and David Grahame Hardie.
  15. Watkins SM., et al. “Neurotoxic shellfish poisoning”. Marine Drugs3 (2008): 431-455.
  16. Abraham WM., et al. “Airway responses to aerosolized brevetoxins in an animal model of asthma”. American Journal of Respiratory and Critical Care Medicine1 (2005): 26-34.
  17. Sayer AN., et al. “The inhibition of CHO-K1-BH4 cell proliferation and induction of chromosomal aberrations by brevetoxins in vitro”. Food Chemistry and Toxicology (2006): 1082-1091.
  18. Walsh PJ., et al. Comparative Biochemistry and Physiology Part B2 (2003): 173-182.
  19. Jennifer R.., et al. “Anti-inflammatory and Immunomodulatory Compounds from Marine Algae”. Marine Drugs 4 (2022): 233.
  20. Rubini S., et al. “New Trends in the Occurrence of Yessotoxins in the Northwestern Adriatic Sea”. Toxins (Basel)9 (2021): 634.
  21. Paz B., et al. “Yesso toxins, a group of marine polyether toxins: an overview”. Marine Drugs2 (2008): 73-102.
  22. Wang DZ., et al. “Neurotoxins from marine dinoflagellates: a brief review”. Marine Drugs2 (2008): 349-371.
  23. Alonso E., et al. “Translocation of PKC by yesso toxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology”. ACS Chem Neuroscience7 (2013): 1062-1070.
  24. Farabegoli F., et al. “Phycotoxins in Marine Shellfish: Origin, Occurrence and Effects on Humans”. Marine Drugs6 (2018): 188.
  25. Botelho MJ., et al. “Alzheimer's Disease and Toxins Produced by Marine Dinoflagellates: An Issue to Explore”. Marine Drugs4 (2022): 253.
  26. Assunção J., et al. “Biotechnological and Pharmacological Applications of Biotoxins and Other Bioactive Molecules from Dinoflagellates”. Marine Drugs12 (2017): 393.
  27. Liu RY., et al. “Cyclic imine toxin gymnodimine: a review”. 20.9 (2009): 2308-2313.
  28. Nieva JA., et al. “Gymnodimine A and 13-desMethyl Spirolide C Alter Intracellular Calcium Levels via Acetylcholine Receptors”. Toxins (Basel)12 (2020): 751.
  29. Rossignoli AE., et al. “First Report of Two Gymnodimines and Two Tetrodotoxin Analogues in Invertebrates from the North Atlantic Coast of Spain”. Marine Drugs4 (2023): 232.
  30. Wu X., et al. “Effects of Culture Systems and Nutrients on the Growth and Toxin Production of Karenia selliformis”. Toxins (Basel) 12 (2024): 518.
  31. Kharrat R., et al. “The marine phycotoxin gymnodimine targets muscular and neuronal nicotinic acetylcholine receptor subtypes with high affinity”. Journal of Neurochemistry4 (2008): 952-963.
  32. Bulić A., et al. “First detection of the gymnodimine A isomer, 13-desmethylspirolide D and pinnatoxin G in mussels from Croatia's southern Adriatic Sea”. Marine Pollution Bulletin 215 (2025): 117888.
  33. Usup G., et al. “Growth and toxin production of the toxic dinoflagellate Pyrodinium bahamense compressum in laboratory cultures”. Natural toxins 2.5 (1993): 254-262.
  34. Li Z., et al. “Selection and application of aptamers with high-affinity and high-specificity against dinophysistoxin-1”. RSC Advances (2020);10 (14): 8181-8189.
  35. Montero MC., et al. “Neosaxitoxin Inhibits the Expression of Inflammation Markers of the M1 Phenotype in Macrophages”. Marine Drugs6 (2020): 283.
  36. Campo M., et al. “In vivo blockade of ovarian sympathetic activity by Neosaxitoxin prevents polycystic ovary in rats”. Journal of Endocrinology 24 (2020).
  37. Fernández DA., et al. “Experimental basis for the high oral toxicity of dinophysistoxin 1: a comparative study of DSP”. Toxins (Basel)1 (2014): 211-28.
  38. Cavion F., et al. “Effects of Dinoflagellate Toxins Okadaic Acid and Dinophysistoxin-1 and -2 on the Microcrustacean Artemia franciscana”. Toxins (Basel)2 (2025): 80.
  39. Huguet A., et al. “Differences in Toxic Response Induced by Three Variants of the Diarrheic Shellfish Poisoning Phycotoxins in Human Intestinal Epithelial Caco-2 Cells”. Toxins (Basel)12 (2020): 783.
  40. Matsushima R., et al. “Assimilation, Accumulation, and Metabolism of Dinophysistoxins (DTXs) and Pectenotoxins (PTXs) in the Several Tissues of Japanese Scallop Patinopectenyessoensis”. Toxins (Basel)12 (2015): 5141-5154.
  41. Boundy MJ., et al. “Risk Assessment of Pectenotoxins in New Zealand Bivalve Molluscan Shellfish, 2009-2019”. Toxins (Basel)12 (2020): 776.
  42. Patricio A Díaz., et al. “Lipophilic Toxins in Chile: History, Producers and Impacts”. Marine Drugs2 (2020): 122.
  43. Reguera B., et al. “Dinophysis Toxins: Distribution, Fate in Shellfish and Impacts”. Toxins (Basel)7 (2019): 413.
  44. Avila C., et al. “Bioactive Compounds from Marine Heterobranchs”. Marine Drugs 18 (2020): 657.
  45. Chakraborty K., et al. “High-value compounds from the molluscs of marine and estuarine ecosystems as prospective functional food ingredients: An overview”. Food Research International 137 (2020): 109637.
  46. Pati P., et al. “Marine molluscs as a potential drug cabinet: An overview”. Indian Journal of Geo-Marine Sciences (IJMS) 44 (2015): 961-970.
  47. Pereira RB., et al. “Chemical diversity and biological properties of secondary metabolites from sea hares of Aplysia genus”. Marine Drugs 14 (2016): 39.
  48. Beaulieu L., et al. “Evidence of anti-proliferative activities in blue mussel (Mytilus edulis) by-products”. Marine Drugs4 (2013): 975-90.
  49. Aldairi AF., et al. “Antiproliferative Activity of Glycosaminoglycan-Like Polysaccharides Derived from Marine Molluscs”. Marine Drugs2 (2018): 63.
  50. Ciavatta ML., et al. “Marine Mollusc-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance”. Med Res Rev.4 (2017): 702-801.
  51. Cui H., et al. “Antiproliferative Activity, Proapoptotic Effect, and Cell Cycle Arrest in Human Cancer Cells of Some Marine Natural Product Extract”. Oxidative Medicine and Cellular Longevity 2020 (2020): 7948705.
  52. Aldairi AF., et al. “Antiproliferative Activity of Glycosaminoglycan-Like Polysaccharides Derived from Marine Molluscs”. Marine Drugs2 (2018): 63.
  53. Kamna R., et al. “Anti-angiogenic Compounds from Marine Organisms and Their Toxicological Effects: A Review”. Revista Brasileira de Farmacognosia 35 (2025): 907-921.
  54. Gupta P., et al. “Screening of antiangiogenic potential of twenty-two marine invertebrate extracts of phylum Mollusca from the South East Coast of India”. Asian Pacific Journal of Tropical Biomedicine 4 (2014): S129-38.
  55. Kasheverov IE., et al. “Marine-Derived Ligands of Nicotinic Acetylcholine Receptors in Cancer Research”. Marine Drugs10 (2025): 389.
  56. Do HN., et al. “Prediction of Specificity of α-Conotoxins to Subtypes of Human Nicotinic Acetylcholine Receptors with Semi-supervised Machine Learning”. ACS Chemistry Neuroscience12 (2025): 2196-2207.
  57. Ekin I., et al. “Molluscs: Their usage as nutrition, medicine, aphrodisiac, cosmetic, jewellery, cowry, pearl, accessory and so on from the history to today”. Middle-East Journal of Scientific Research 4 (2018): 45-45.
  58. Ngandjui YAT., et al. “Nutraceutical and Medicinal Importance of Marine Molluscs”. Marine Drugs5 (2024): 201.
  59. Chen N., et al. “Structures and Anti-Allergic Activities of Natural Products from Marine Organisms”. Marine Drugs3 (2023): 152.
  60. V A Toptikov., et al. “Kovtun Proteolytic Activity of Enzymes in Organs of the Black Sea Mollusks”. Hydrobiological Journal2 (2024): 66-76.
  61. Muhammad Hussnain Siddique, et al., “Antidiabetic and antioxidant potentials of Abelmoschus esculentus: In vitro combined with molecular docking approach”. Journal of Saudi Chemical Society2 (2022): 101418.
  62. Pavlina Dolashk., et al. “Bioactive compounds isolated from Garden snail”. Biological Sciences and Biotechnology (2016).
  63. Rodriguez A., et al. “Identification and Characterisation of Three New Antimicrobial Peptides from the Marine Mollusc Nerita versicolor (Gmelin, 1791)”. International Journal of Molecular Sciences 4 (2023): 3852.
  64. González García M., et al. “New Antibacterial Peptides from the Freshwater Mollusc Pomaceapoeyana (Pilsbry, 1927)”. Biomolecules11 (2020): 1473.
  65. Reda R., et al. “Anti-parasitic activity of garlic (Allium sativum) and onion (Allium cepa) extracts against Dactylogyrus (Monogenean) in Nile tilapia (Oreochromis niloticus): Hematology, immune response, histopathological investigation, and inflammatory cytokine genes of gills”. BMC Veterinary Research 20 (2024): 334.
  66. Wijesekera K., et al. “Anthelmintic Potential of Agelasine Alkaloids from the Australian Marine Sponge Agelasaxifera”. Marine Drugs 23 (2025): 276.
  67. Ahmad TB., et al. “Review of anti-inflammatory, immune-modulatory and wound healing properties of molluscs”. Journal of Ethnopharmacology 210 (2018): 156-178.
  68. Jimenez EC., et al. “Conantokin-L, a new NMDA receptor antagonist: determinants for anticonvulsant potency”. Epilepsy Research1-2 (2002): 73-80.
  69. Sher E., et al. “Omega-conotoxin-sensitive voltage-operated calcium channels in vertebrate cells”. Neuroscience 42.2 (1991): 301-307.
  70. Nielsen CK., et al. “Anti‐allodynic efficacy of the chi‐conopeptide, Xen2174, in rats with neuropathic pain”. Pain 118 (2005): 112-
  71. Wudayagiri Rajendra., et al. “Toxins in anti-nociception and anti-inflammation”. Toxicon 1 (2004).
  72. Livett BG., et al. “Therapeutic applications of conotoxins that target the neuronal nicotinic acetylcholine receptor”. Toxicon7 (2006): 810-829.
  73. Min Pang., et al. “Elevated pCO2 may increase the edible safety risk of clams exposed to toxic Alexandrium spp”. Science of The Total Environment 954 (2024): 176610.
  74. Pelin M., et al. “Azaspiracids Increase Mitochondrial Dehydrogenases Activity in Hepatocytes: Involvement of Potassium and Chloride Ions”. Marine Drugs5 (2019): 276.
  75. , et al. “Enzymatic Biotransformation of 13-desmethyl Spirolide C by Two Infaunal Mollusc Species: The Limpet Patella vulgata and the Cockle Cerastoderma edule”. Toxins 14.12 (2022): 848.

Citation

Citation: Kriti Shah and Ravi Kant Upadhyay. “Therapeutic, Pharmacological and Biomedical Uses of Marine and Terrestrial Molluscs: A Review". Acta Scientific Pharmaceutical Sciences 10.1 (2026): 18-33.

Copyright

Copyright: © 2026 Kriti Shah and Ravi Kant Upadhyay. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate32%
Acceptance to publication20-30 days

Indexed In




News and Events


  • Publication Certificate
    Authors will be provided with the Publication Certificate after their successful publication
  • Last Date for submission
    Authors are requested to submit manuscripts on/before February 10, 2026, for the second issue of 2026.

Contact US