Ibrahim Muhammad^1,4,5, Mustapha Abdullahi Huguma¹, Shehu Yakubu Magaji², and Suleiman Yunusa³*

¹Department of Pharmacology and Therapeutics, Bayero University Kano, 3011 Kano, Nigeria
²Department of clinical Pharmacology and Therapeutics, College of medical sciences, Abubakar Tafawa Balewa University Bauchi State, Nigeria
³Department of Pharmacology, Sa’adu Zungur University, PMB 65 Itas Gadau, Bauchi State, Nigeria
⁴Ministry of Health, Bauchi State, Nigeria
⁵Department of Pharmacology, Federal University of Health Sciences, Azare, Bauchi State, Nigeria

*Corresponding Author: Ibrahim Muhammad, Department of Pharmacology, Federal University of Health Sciences, Azare, Bauchi State, Nigeria and Suleiman Yunusa, Department of Pharmacology, Sa’adu Zungur University, PMB 65 Itas/Gadau, Bauchi State, Nigeria.

Received: July 22, 2025; Published: September 23, 2025

Abstract

Introduction: Eragrostis cilianensis has been used widely for many purposes, however, its safety profile has not yet been well documented. This study assesssed the impact of single and repeated dosing of Eragrostis cilianensis ethanol extract on nephrone, hepatic and hematological parameters.

Methodology: The plant was extracted by cold maceration using 70% v/v ethanol based on the standard protocol. The acute and subchronic toxicity studies were evaluated using OECD 425 and 407 guidelines respectively. Effects of the extract on biochemical, hematological and histopathological markers were assessed.

Results: The oral median lethal dose (LD50) of the extract in rats, was found to be greater than 5000 mg/kg. The sub chronic toxicity study of the extract following 28 days daily administration revealed no statistically significant differences (p > 0.05) in the renal, hepatic, and haematological function biomarkers. However, the kidney photomicrographs revealed a slight distortion in the histology. In conclusion, the extract appears to be relatively safe at the tested doses; however, caution is advised in individuals with underlying kidney disease.

Keywords: Eragrostis cilianensis; Toxicity Studies; Renals; Hepatic; And Hematological Parameters

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Citation

Citation: Ibrahim Muhammad., et al. “Acute and Subchronic Toxicity Assessment of Eragrostis cilianensis All. Lut. Ethanol Extract: Effects on Renal, Hepatic, and Hematological Parameters". Acta Scientific Pharmaceutical Sciences 9.10 (2025): 26-32.

Copyright

Copyright: © 2025 Ibrahim Muhammad., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.