Gayatri Rai¹, Narendra Namdev² and Payal Mahobiya³*

¹Department of Zoology, Govt. P. G. College Guna (M.P.), India
²Department of Zoology, Shri Krishna University, Chhatarpur, (M.P.) India
³Department of Zoology, Dr. Harisingh Gour Central University, Sagar, (M.P.) India

*Corresponding Author: Payal Mahobiya, Associate Professor, Department of Zoology, Dr. Harisingh Gour Central University, Sagar, M.P. India.

Received: March 31, 2025; Published: April 11, 2025

This study evolute the protective role of tropical medicine curcumin and ascorbic acid against ultraviolet B (UVB) exposure in female Wistar rats. The Experimental study consisted of 24 rats, divided into four groups, each comprising six animals. Group was named Group first Control, second ultraviolet B (2 hours/day) induced hyperthyroidism group, third ultraviolet B induced hyperthyroidism group, and after 30 min given curcumin (25mg/kg BW) orally, and last fourth ultraviolet B induced hyperthyroidism and after 30 min given ascorbic acid (250mg/kg BW) orally. The duration of each treatment is 15 days straight. The liver marker changes were measured by methods. The histopathological and apoptotic changes in the liver were done by different staining and Caspase 3, and observed the slides under the compound and confocal microscope. UVB radiation damaged the liver cells and showed cellular injury. Curcumin and ascorbic acid protected UVB radiation-induced changes in liver. Little doses of both antioxidants can reduce liver marker responses and histological changes brought on by UVB radiations in Wistar rat’s cells. The liver's ability to function was impeded by UVB radiation, which was also seen as liver damage by several stains. Female Wistar rats' livers exhibited protective effects from curcumin and ascorbic acid.

Keywords: Liver; UVB; Histology; Tropical Medicine; Hyperthyroidism; Apoptosis

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Citation

Citation: Payal Mahobiya., et al. “Hepatoprotective Effect of Tropical Medicine Curcumin and Ascorbic Acid against the Ultraviolet B Irradiated Hyperthyroidism Female Wistar Rat". Acta Scientific Pharmaceutical Sciences 9.5 (2025): 18-21.

Copyright

Copyright: © 2025 Payal Mahobiya., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.