Asha Jyothi V*, Siddiqua Nida and Syeda Safoora Imad

Department of Pharmacology, Shadan Women’s College of Pharmacy, Khairtabad, Hyderabad, India

*Corresponding Author: Asha Jyothi V, Department of Pharmacology, Shadan Women’s College of Pharmacy, Khairtabad, Hyderabad, India.

Received: March 24, 2025; Published: April 09, 2025

Nutraceuticals such as Saraca celebica W.J Wilde and Asparagus fallax were extracted by ethanolic extract. These extracts were subjected to examine pharmacological action by centrally acting analgesic activity using tail immersion method and peripheral acting analgesic activity using acetic acid induced writhing test in rats. The crude extract of the plant was found to have significant (p < 0.01) analgesic activity at the oral dose in the test models of tail immersion, Saraca celebica W.J Wilde showed increased time latency than Asparagus fallax, where as in acetic acid induced writhing test Asparagus fallax showed reduced number of writhes than Saraca celebica W.J Wilde at dose levels which have significant (p < 0.001) compared to control. The result obtained support the use of the plants Saraca celebica W.J Wilde and Asparagus fallax in painful condition acting both centrally and peripherally.

Keywords: Saraca celebica W.J Wilde Analgesic Activity; Asparagus fallax

References

1. Pathak K and Das J R. “Herbal Medicine- A Rational Approach in Health Care System”. IJHM3 (2013): 86-89.
2. Magaji GM., et al. “Preliminary studies on anti-inflammatory and analgesic activities of Securinega virosa (Euphorbiaceae) in experimental animal models”. JMPR 2 (2008): 039-044.
3. Chungag NBN., et al. “Analgesic and anti-inflammatory properties of Oxyanthus unilocularis”. JMPR10 (2010): 932-939.
4. Usha G., et al. “Plants Possessing Potential Analgesic And Anti-Inflammatory Activities: A Review”. SAJP1 (2012): 18-23.
5. Deepika L P., et al. “Analgesic, Antiinflammatory Activity of Tinospora Cordifolia (Guduchi) and Valeriana Wallichi (Tagara) In Albino Rats”. IOSR-JPBS2 (2016): 18-22.
6. Hasan R M S., et al. “Analgesic and Antioxidant Activity of the Hydromethanolic Extract of Mikania scandens (L.) Willd. Leaves”. AJPT1 (2009): 1-7.
7. Akuodor G C., et al. “Pharmacological profile of aqueous extract of Bridelia ferruginea stem bark in the relief of pain and fever”. JMPR22 (2011): 5366-5369.
8. Jigam A A., et al. “In vivo antiplasmodial, analgesic and anti-inflammatory activities of the leaf extract of Lippia multiflora mold”. JMPR3 (2009): 148-154.
9. C K Kokate., et al. “Pathway to screen phytochemical nature of natural drugs”. Pharmacognosy, Nirali Prakashan, Pune, (2005): 593-597.
10. Suleiman M M., et al. “Anti-inflammatory and Antinociceptive Effects of the Methanol Extract of Indigofera arrecta Hochst-Holl. in Rodents”. AJPT3 (2015): 72-79.
11. Khandelwal K R. “Practical pharmacognosy”. Nirali Prakashan Pune. 19^th (2008): 149-156.
12. OECD Guideline for Testing of Chemicals. Acute Oral Toxicity – Fixed Dose Procedure, 420 Adopted: 17th December; (2001).
13. Vogel GH. “Drug discovery and evaluation-pharmacological assay”. 2^nd
14. Pendota SC., et al. “Anti-inflammatory, analgesic and antipyretic activities of the aqueous extract of Hippobromus pauciflorus (L.f) Radlk leaves in male Wistar rats”. AJB 10 (2009): 2036-2041.
15. Krishnaveni M., et al. “Antiinflammatory and analgesic actions of 4’,5,6-trihydroxy- 3’7-dimethoxy flavone-from vicoa indica dc”. IJP3 (1977): 178-181.
16. Shwetha R., et al. “Antinociceptive Screening of Methanol Extract of Anogeissus Accuminate”. RJPBCS2 (2013): 238-242.
17. Turner R A. “Screening methods in pharmacology”. Academic press, New York (1965): 100.
18. Zulfiker AHM., et al. “In vivo analgesic activity of ethanolic extracts of two medicinal plants - Scoparia dulcis and Ficus racemosa Linn”. BNM 2(2 (2010): 42-48.
19. Khan S., et al. “Studies on anti-inflammatory and analgesic activities of betel nut in rodents”. PEP 135 (2011): 654-661.
20. , et al. “AntiInflammatory and Analgesic Activity of Medicinal Plants-A Review”. IJPE 4.3 (2014).
21. Asha Jyothi V., et al. “Analgesic Activity of Herbal Plants - A Review”. JCHPS3 (2024): 20-42.

Citation

Citation: Asha Jyothi V., et al. “Phytochemical Evaluation and Pharmacological Screening of Saraca celebica W.J Wilde and Asparagus fallax Plant Extract for Central and Peripheral Analgesic Activity". Acta Scientific Pharmaceutical Sciences 9.5 (2025): 03-07.

Copyright

Copyright: © 2025 Asha Jyothi V., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.