Nagadharshini R ^1,2and SP Suriyaraj ¹

¹RAISE Centre for Nanobiotechnology, AIC RAISE, Rathinam Techzone, Eachanari, Coimbatore 641021, Tamil Nadu, India ²Department of Biotechnology, Rathinam College of Arts & Science, Pollachi Road, Eachanari, Coimbatore 641021, Tamil Nadu, India

*Corresponding Author: SP Suriyaraj, RAISE Centre for Nanobiotechnology, AIC RAISE, Rathinam Techzone, Eachanari, Coimbatore 641021, Tamil Nadu, India.

Received: January 09, 2025; Published: January 30, 2025

Abstract

Nigella sativa, commonly known as Black Cumin seed, has been traditionally used for its medicinal properties and used in various healthcare application. Diabetic wounds represent a significant challenge in medical care due to their tendency for slow healing and high risk of complications. Nigella sativa attributed to its active compounds such as thymoquinone, thymohydroquinone, and dithymoquinone. Recent studies have explored its potential in promoting wound healing, especially in the context of diabetes. This review aims to consolidate current knowledge on the efficacy of Nigella sativa in management of diabetic wound care, The Key active compounds, including thymoquinone, exhibit notable anti-inflammatory, antioxidant, and antimicrobial activities, which are crucial for effective wound healing. Studies demonstrate that Nigella sativa extracts can accelerate wound closure, reduce inflammation, and combat microbial infections, thereby enhancing the overall wound healing process in diabetic patients. Additionally, Nigella sativa ability to modulate immune responses and promote collagen synthesis further supports its application in diabetic wound care, thus facilitating better wound management in diabetic patients. Wounds Despite encouraging preclinical results, comprehensive clinical trials are necessary to establish its efficacy and safety in human subjects. Integrating Nigella sativa into diabetic wound management protocols could offer a promising, natural adjunct to existing therapeutic options, improving outcomes for patients with diabetic wounds.

Keywords: Nigella sativa; Thymoquinone; Thymohydroquinone; Dithymoquinone; Diabetic Wound; Wound Healing

References

1. Aftab Ahmad., et al. “A review on therapeutic potential of Nigella sativa: A miracle herb”. Asian Pacific Journal of Tropical Biomedicine5 (2013): 337-352.
2. Abid Nordin., et al. “Effect of Nigella sativa and its bioactive compound on type 2 epithelial to mesenchymal transition: a systematic review”. BMC Complementary and Alternative Medicine1 (2019): 290.
3. Ahmadi Yusmin and Norhayati Ahmad. “Effect of thymoquinone on wound healing in alloxan-induced diabetic rats”. 10.9 (2017).
4. Anum Javed., et al. “Nigella sativa a Potent Healer for Diabetic Wounds and Its Other Pharamcognosal attributes”. (2019).
5. Ayse Usta Semiha Dede. “The Effect of Thymoquinone on Nuclear Factor Kappa B Levels and Oxidative DNA Damage on Experimental Diabetic Rats”. 13 (2017): S458-S461.
6. Betul Apaydin Semin Gedikli. “Wound healing effects of Nigella sativa essential oil in streptozotocin induced in diabetic rats”. GSC Biological and Pharmaceutical Sciences (2017).
7. Cansu Aras., et al. “Evaluation of Nigella sativa oil loaded electrospun polyurethane nanofibrous mat as wound dressing”. Journal of Biomaterials Science, Polymer Edition13 (2021): 1718-1735.
8. Chella Perumal Palanisamy., et al. “Biosynthesis of silver nanoparticles (AgNPs) using ethanolic extract of Nigella sativa (L.) seeds promotes wound healing via PDGF and VEGF signalling pathways activation”. (2023).
9. Dadih Supriadi. “Study Effectiveness and Stability Formulation Nanoemulsion of Black Cumin Seed (Nigella sativa) Essential Oil: A Review”. (2022).
10. Elham Nourbar., et al. “Effect of Hydroethanolic Extract of Nigella sativa on Skin Wound Healing Process in Diabetic Male Rats”. 10 (2020): 18.
11. Eliza Arman., et al. “Combined Effect Of Topical Application Of Virgin Coconut Oil (Vco) And Black Cumin Oil (Nigella sativa) On The Upregulation Of Vegf Gene Expression And Wound Healing In Diabetic Ulcerated Rats”. International Journal of Applied Pharmaceutics (2024).
12. Giuseppe Derosa., et al. “The Use of Nigella sativa in Cardiometabolic Diseases”. Biomedicines 2 (2024): 405.
13. Heba M A Abdelrazek., et al. “Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats”. 4 (2018): 8104165.
14. Jamie L Burgess., et al. “Diabetic Wound-Healing Science”. Medicina10 (2021): 1072.
15. Javad Heshmati and Nazli Namazi. “Effects of black seed (Nigella sativa) on metabolic parameters in diabetes mellitus: a systematic review”. Complementary Therapies in Medicine2 (2015): 275-282.
16. Junfang Liang., et al. “Thymoquinone, extract from Nigella sativa seeds, protects human skin keratinocytes against UVA-irradiated oxidative stress, inflammation and mitochondrial dysfunction”. Molecular Immunology 135 (2021): 21-27.
17. Kamila Raziyeva., et al. “Immunology of Acute and Chronic Wound Healing”. Biomolecules5 (2021): 700.
18. Lorina Badger Emeka., et al. “Antimicrobial activity of Nigella sativa seed oil against multi-drug resistant Staphylococcus aureus isolated from diabetic wounds”. 28.6 (2015): 1985-1990.
19. Maha I Alkhalaf., et al. “Green synthesis of silver nanoparticles by Nigella sativa extract alleviates diabetic neuropathy through anti-inflammatory and antioxidant effects”. (2020).
20. Mahmoud Balbaa., et al. “Nigella sativa Relieves the Altered Insulin Receptor Signaling in Streptozotocin-Induced Diabetic Rats Fed with a High-Fat Diet”. Oxidative Medicine and Cellular Longevity 2016 (2016): 2492107.
21. Mahmoud Balbaa., et al. “Oxidative stress and expression of insulin signaling proteins in the brain of diabetic rats: Role of Nigella sativa oil and antidiabetic drugs”. Plos One5 (2017): e0172429.
22. Majed Alwadei., et al. “Novel oral dosage regimen based on self-nanoemulsifying drug delivery systems for codelivery of phytochemicals - Curcumin and thymoquinone”. Saudi Pharmaceutical Journal6 (2019): 866-876.
23. Mehmet Kanter., et al. “Effects of Nigella sativa on Oxidative Stress and β-Cell Damage in Streptozotocin-Induced Diabetic Rats” (2004).
24. Meshari A Alzahrani., et al. “Effect of Black Cumin (Nigella sativa) on Prostate Health: Narrative Review”. (2024).
25. Mohammad Reza Mahmoodi and Mehdi Mohammadizadeh. “Therapeutic potentials of Nigella sativa preparations and its constituents in the management of diabetes and its complications in experimental animals and patients with diabetes mellitus: A systematic review”. Complementary Therapies in Medicine 50 (2020): 102391.
26. Mohammed Saad Almuhayawi. “Efficacy of Nigella sativa in Wound Healing”. (2023).
27. M S Al-Ghamdi. “The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa”. Journal of Ethnopharmacology 1 (2001): 45-48.
28. Muhammad H Alu'datt., et al. “Designing novel industrial and functional foods using the bioactive compounds from Nigella sativa (black cumin): Biochemical and biological prospects toward health implications”. Journal of Food Science 89.4 (2024): 1865-1893.
29. Nusaibah Sallehuddin., et al. “Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review”. (2020).
30. P J Houghton., et al. “Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation”. Planta Medica1 (1995): 33-36.
31. Rabab Hajwal Al-Zamily., et al. “Comparison Of The Effects Of Nigella sativa Oil And Laser On Treatments On Experimental Wound Healing In Rats”. (2019).
32. Retno Susilowati., et al. “Effective Combination of Nigella sativa and Trigonella foenum-graecum Seed Extract on Wound Healing in Diabetic Mice”. (2023).
33. R M Shrivastava., et al. “A Review on Therapeutic Applications of Nigella sativa A Review on Therapeutic Applications of Nigella sativa”. Asian Pacific Journal of Tropical Biomedicine5 (2011).
34. Satish Patel., et al. “Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing”. Biomedicine and Pharmacotherapy 112 (2019): 108615.
35. Serkan Sen and Murat Kasikci. “Low-dose rosmarinic acid and thymoquinone accelerate wound healing in retinal pigment epithelial cells”. International Ophthalmology10 (2023): 3811-3821.
36. Shifali Thakur., et al. “Nigella sativa (Kalonji): A Black Seed of Miracle”. International Journal of Research and Review 4 (2021).
37. Syeda Asra Banu., et al. “Nigella sativa – A Herbal Remedy for All Ailments Except Death”. (2022).
38. Wesam Kooti., et al. “Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa)”. 14.10 (2016): 732-745.
39. Yunita Sari., et al. “A Comparative Study of the Effects of Nigella sativa Oil Gel and Aloe Vera Gel on Wound Healing in Diabetic Rats”. 23 (2018): 2515690X18772804.

Citation

Citation: Nagadharshini R and SP Suriyaraj. “Nigella sativa and its Role in Diabetic Wound Management: A Review of Therapeutic Applications". Acta Scientific Pharmaceutical Sciences 9.2 (2025): 12-23.

Copyright

Copyright: © 2025 Nagadharshini R and SP Suriyaraj. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.