Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 8 Issue 7

Antioxidant Effects of Supplementation with Choice Vitamins C (Ascorbic Acid) And E (Tocopherol) on Rohypnol-Induced Kidney Damage of Male Wistar Rats

Hyacinth Tochukwu Eze1, Ezejindu Damian Nnabuihe2, Joshua Izuchukwu Abugu2* and Ifeanacho Ezeteonu Abireh3

1Department of Internal Medicine, Nnamdi Azikiwe University, College of Medicine Nnewi Campus, Anambra State, Nigeria
2Department of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
3Department of Anatomy, Faculty of Basic Medical Sciences, Enugu State University of Science and Technology, Enugu State, Nigeria

*Corresponding Author: Joshua Izuchukwu Abugu, Department of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.

Received: May 27, 2024; Published: June 11, 2024


This study was principally carried out to investigate the effect of Vitamins C and E on the rohypnol-induced kidney damage in male wistar rats. Twenty five adult male wistar rats were randomly divided into four groups with five rats in each group (A, B, C, D and E). Group A, the control group received distilled water. Groups B, C and D received 1 mg/kg of Rohypnol, 1 mg/kg of Rohypnol+100 mg/kg of vitamin C, 1 mg/kg of Rohypnol+100 mg/kg of vitamin E and 1 mg/kg of Rohypnol+100 mg/kg of vitamin C and E of Rohypnol respectively. The animals were anaesthesized under ketamine followed by cardiac puncture after three weeks of administration and the kidney were harvested and fixed in 10% formal saline for histological processing, blood were collected via cardiac puncture for biochemical studies. The results obtained in this study following the administration of Vitamin C&E and increasing dosage of rohypnol shows a progressive improvement in the test group when comparing to the other group. The crucial role of Vitamin C and E in renal functions, as well as responses to the histoarchitecture is well supported by the evidences presented in this study.

Keywords: Flunitrazepam Vitamin C and E (Rohypnol), Kidney; Histoarchitecture; Benzodiazepine


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Citation: Joshua Izuchukwu Abugu., et al. “Antioxidant Effects of Supplementation with Choice Vitamins C (Ascorbic Acid) And E (Tocopherol) on Rohypnol-Induced Kidney Damage of Male Wistar Rats".Acta Scientific Pharmaceutical Sciences 8.7 (2024): 36-43.


Copyright: © 2024 Joshua Izuchukwu Abugu., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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