Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 7 Issue 11

Synthesis, Characterization and Anti-bacterial Activity of Co(II) and Ni(II) Complexes with a NSO Donating Site Schiff Base Ligand Derived from N-ethylhydrazinecarbothioamide and 5-bromo-2-hydroxy-3-methoxybenzaldehyde

Afnan Islam and Md Azharul Arafath*

Department of Chemistry, Shahjalal University of Science and Technology, Bangladesh

*Corresponding Author: Md Azharul Arafath, Department of Chemistry, Shahjalal University of Science and Technology, Bangladesh.

Received: August 21, 2023; Published: October 06, 2023


A NSO tridentate Schiff base ligand (E)-2-(5-bromo-2-hydroxy-3-methoxybenzylidene)-N-ethyledrazine-1-carbothioamide (L1) of a new carbothioamide has been synthesized. Co2+ and Ni2+ metal was introduced to tridentate Schiff base ligand to make coordination complexes. Square planar complex of Ni2+ and octahedral complex of Co2+ metal-ions were formed respectively and compounds Na [NiLCl] and Na [CoL(OH2)2Cl] have been found under basic condition. Characterization of these compounds are done by on the basis of melting point, FT-IR spectroscopy and UV-Visible spectroscopy. As the new complexes possesses azomethine(=C=N−) group so they have potential biological activity. For antibacterial study the solution of complexes and ligand was applied against the bacteria S. aureus and B. subtilis to find out their inhibition with bacteria.

Keywords: Thiosemicarbazone; Schiff Base Ligand; Cobalt Complex; Nickel Complex; FT-IR Spectroscopy; UV-Visible Spectroscopy


  1. R H Holm., et al. “Metal Complexes of Schiff Bases and β-Ketoamines”. in Progress in Inorganic Chemistry, F. A. Cotton, Ed. Hoboken, NJ, USA: John Wiley and Sons, Inc., (2007): 83-214.
  2. P A Vigato and S Tamburini. “The challenge of cyclic and acyclic schiff bases and related derivatives”. Coordination Chemistry Reviews 17-20 (2004): 1717-2128.
  3. H Schiff. “Mittheilungen aus dem Universitätslaboratorium in Pisa: Eine neue Reihe organischer Basen”. Annalen der Chemie und Pharmacie 1 (1864): 118-119.
  4. I Beloso., et al. “Flexidentate Behaviour of 2‐Pyridylsulfonamides − Direct Electrochemical Synthesis and Spectroscopic and X‐ray Characterisation of Neutral Copper (II) Complexes of N ‐ (2‐Pyridyl)sulfonamides”. European Journal of Inorganic Chemistry 3 (2004): 635-645.
  5. Chemistry, The Madura College, / Madurai Kamaraj University, India, Dr. A. Xavier, and N. Srividhya. “Synthesis and Study of Schiff base Ligands”. IOSR Journal of Applied Chemistry 11 (2014): 06-15.
  6. C Ainsworth. “Principles of modern heterocyclic chemistry (Paquette, Leo A.)”. Journal of Chemical Education 9 (1969): 624.
  7. P Selvam., et al. “Synthesis and anti-HIV activity of 4- (1,2-dihydro-2-oxo-3H-indol-3-ylidene) amino.-N (4,6-dimethyl-2-pyrimidinyl)-benzene sulfonamide and its derivatives”. European Journal of Pharmaceutical Sciences 4 (2001): 313-316.
  8. R B Singh., et al. “Analytical applications of thiosemicarbazones and semicarbazones: A review”. Talanta11-12 (1978): 619-632.
  9. U Kulandaivelu., et al. “Synthesis, Antimicrobial and Anticancer Activity of New Thiosemicarbazone Derivatives”. Pharm. (Weinheim) 344.2 (2011): 84-90.
  10. W Hernández., et al. “Synthesis, Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives and Their Palladium (II) and Platinum (II) Complexes against Various Human Tumor Cell Lines”. Bioinorganic Chemistry and Applications (2008): 1-9.
  11. B Prathima., et al. “Copper (II) and nickel (II) complexes of benzyloxybenzaldehyde-4-phenyl-3-thiosemicarbazone: Synthesis, characterization and biological activity”. Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy 1 (2010): 248-252.
  12. P Kalaivani., et al. “Influence of terminal substitution on structural, DNA, Protein binding, anticancer and antibacterial activities of palladium (ii) complexes containing 3-methoxy salicylaldehyde-4 (N) substituted thiosemicarbazones”. Dalton Transaction 8 (2012): 2486.
  13. A J Kesel. “Broad-spectrum antiviral activity including human immunodeficiency and hepatitis C viruses mediated by a novel retinoid thiosemicarbazone derivative”. European Journal of Medicinal Chemistry 5 (2011): 1656-1664.
  14. EF Castro., et al. “Inhibition of Bovine Viral Diarrhea Virus RNA Synthesis by Thiosemicarbazone Derived from 5,6-Dimethoxy-1-Indanone”. Journal of Virology 11 (2011): 5436-5445.
  15. D L Klayman., et al. “2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents”. Journal of Medicinal Chemistry 7 (1979): 855-862.
  16. G L Parrilha., et al. “Pyridine-derived thiosemicarbazones and their tin (IV) complexes with antifungal activity against Candida spp.”. European Journal of Medicinal Chemistry 5 (2011): 1473-1482.
  17. T S Lobana., et al. “Bonding and structure trends of thiosemicarbazone derivatives of metals—An overview”. Coordination Chemistry Reviews 7-8 (2009): 977-1055.
  18. D E Barber., et al. “Silane alcoholysis by a nickel (II) complex in a N, O, S ligand environment”. Inorganic Chemistry 22 (1992): 4709-4711.
  19. R P John., et al. “New copper (II) complexes of 2-hydroxyacetophenone N (4)-substituted thiosemicarbazones and polypyridyl co-ligands: structural, electrochemical and antimicrobial studies”. Polyhedron16 (2004): 2549-2559.
  20. M A Ali., et al. “Four- and five-coordinate copper (II) complexes containing mixed ligands”. Polyhedron5 (1984): 595-598.
  21. P Bindu., et al. “Epr, cyclic voltammetric and biological activities of copper (II) complexes of salicylaldehyde N (4)-substituted thiosemicarbazone and heterocyclic bases”. Polyhedron3-4 (1998): 321-331.
  22. Z Lu., et al. “Deprotonated thioamides as thiolate S-donor ligands with a high tendency to avoid M-S-M bridge formation: crystal and molecular structure of bis (2-hydroxy-5-methylacetophenone N,N-dimethylthiosemicarbazonato)dinickel”. Inorganic Chemistry 19 (1993): 3991-3994.
  23. S Samanta., et al. “Utilization of LVO−2 species (L2− is a tridentate ONS donor) as an inorganic analogue of carboxylate group: A journey to a new domain of coordination chemistry”. Journal of Chemical Sciences 6 (2006): 475-486.
  24. S Padhyé and G B Kauffman. “Transition metal complexes of semicarbazones and thiosemicarbazones”. Coordination Chemistry Reviews 63 (1985): 127-160.
  25. A E Liberta and D X West. “Antifungal and antitumor activity of heterocyclic thiosemicarbazones and their metal complexes: current status”. Biometals2 (1992): 121-126.
  26. E Lukevics., et al. “Neurotropic activity of aldehyde and ketone thiosemicarbazones with a heterocyclic component”. European Journal of Medicinal Chemistry 12 (1995): 983-988.
  27. R W Chesnut., et al. “Antibacterial activity of 15-azasteroids alone and in combination with antibiotics”. Steroids4 (1976): 525-541.
  28. G Y Nagesh and B H M Mruthyunjayaswamy. “Synthesis, characterization and biological relevance of some metal (II) complexes with oxygen, nitrogen and oxygen (ONO) donor Schiff base ligand derived from thiazole and 2-hydroxy-1-naphthaldehyde”. Journal of Molecular Structure 1085 (2015): 198-206.
  29. I C Mendes., et al. “Coordination to copper (II) strongly enhances the in vitro antimicrobial activity of pyridine-derived N (4)-tolyl thiosemicarbazones”. Polyhedron13 (2007): 3263-3270.
  30. M Salehi., et al. “Structural, spectroscopic, electrochemical and antibacterial studies of some new nickel (II) Schiff base complexes”. Inorganica Chimica Acta 443 (2016): 28-35.
  31. D X West., et al. “Nickel (II) complexes of 2-aminoacetophenone N (4)-substituted thiosemicarbazones”. Transition Metal Chemistry (1998): 5.
  32. R K Agarwal., et al. “Synthesis, Spectral, and Biological Properties of Copper (II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes”. Bioinorganic Chemistry and Applications (2006): 1-10.
  33. A P Rebolledo., et al. “Tin (IV) complexes of 2-benzoylpyridine N (4)-phenyl-thiosemicarbazone: spectral characterization, structural studies and antifungal activity: Tin (IV) complexes of 2-benzoylpyridine N (4)-phenylthiosemicarbazone”. Applied Organometallic Chemistry 12 (2003): 945-951.
  34. T N Sorrell., et al. “Synthesis and characterization of phenolate-bridge copper dimers with a copper-copper separation of >3.5 .ANG.. Models for the active site of oxidized hemocyanin derivatives”. Journal of the American Chemical Society 14 (1985): 4199-4206.
  35. M F Iskander., et al. “Synthesis, characterization and magnetochemical studies of dicopper (II) complexes derived from bis (N- salicylidene)dicarboxylic acid dihydrazides”. Journal of Coordination Chemistry 2 (2005): 125-139.
  36. S M Nasman. “N 2 S 2 -Donor Macrocycles with Some Transition Metal Ions: Synthesis and Characterization”. Phosphorus, Sulfur, and Silicon and the Related Elements 7 (2008): 1541-1551.
  37. B Bosnich. “An interpretation of the circular dichroism and electronic spectra of salicylaldimine complexes of square-coplanar diamagnetic nickel (II)”. Journal of the American Chemical Society 3 (1968): 627-632.


Citation: Afnan Islam and Md Azharul Arafath. “Synthesis, Characterization and Anti-bacterial Activity of Co(II) and Ni(II) Complexes with a NSO Donating Site Schiff Base Ligand Derived from N-ethylhydrazinecarbothioamide and 5-bromo-2-hydroxy-3-methoxybenzaldehyde".Acta Scientific Pharmaceutical Sciences 7.11 (2023): 15-21.


Copyright: © 2023 Afnan Islam and Md Azharul Arafath. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate32%
Acceptance to publication20-30 days

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 30, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US