Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 7 Issue 10

Histomorphology and Nephroprotective Effect of Cajanus cajan in Lead-acetate-Induced Kidney Damage

Nwanama Emmanuel Kenechukwu1, Ogbo, Felix Ovie2, Mbang Joshua Egbe1* and Mayaki, Esther Oluwatoyin1

1Department of Anatomy, Faculty of Basic Medical Sciences, Edo State University, Edo State, Nigeria
2Department of Anatomy, Gregory University Uturu, Abia State, Nigeria
3Department of Anatomy, Faculty of Basic Medical Sciences, University of Calabar, Cross Rivers State, Nigeria

*Corresponding Author: Mbang Joshua Egbe, Department of Anatomy, Faculty of Basic Medical Sciences, University of Calabar, Cross Rivers State, Nigeria

Received: September 05, 2023; Published: September 23, 2022


Background:Nephrotoxicity results from an overload of chemicals and drugs including Lead-acetate (Pb), an environmental pollutant. This study examined the nephroprotective potential of Cajanus cajan in male Wistar rats.

Material and Methods: Nephrotoxicity was induced by exposure to Lead at 20mg/kg while Cajanus cajan was administered at 200mg/kg, 400mg/kg and 800mg/kg for 14 days. Markers of nephrotoxicity including urea and serum creatinine were evaluated, and histoarchitecture alteration of the tissue was examined.

Results: The lead exposed group showed a marginal increase in urea and serum creatinine significantly (p < .05) compared to control values. The Cajanus cajan-treated groups showed a significant (p < .05) decrease respectively in urea and serum creatine. Cajanu cajan protected kidney tissue morphology.

Conclusion: The results indicate that Cajanus cajan protected Kidneys against Lead-induced toxicity

Keywords: Microplastic; Ocean Water; Surface Water; Drinking Water; Aquatic Ecosystem; Human Health


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Citation: Mbang Joshua Egbe., et al. “Histomorphology and Nephroprotective Effect of Cajanus cajan in Lead-acetate-Induced Kidney Damage". Acta Scientific Pharmaceutical Sciences 7.10 (2023): 56-60.


Copyright: © 2023 Mbang Joshua Egbe., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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