Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 7 Issue 9

Forced Degradation Studies for Estimation of Finerenone by RP-HPLC Method

Janga Rameshbabu*, Sunkara Sivaprasad, Battula Sowjanya Lakshmi and Suryadevara Vidyadhara

Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, India

*Corresponding Author: Janga Rameshbabu, Professor and H.O.D, Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, India.

Received: June 19, 2023; Published: August 19, 2023

Abstract

The goal of a sustained release dosage form is to maintain therapeutic blood or tissue levels of the drug for an extended and specified period of time. The aim of this study was to formulate and evaluate sustained release microspheres of Venlaflaxin Hydrochloride. Sustained release microspheres were obtained by solvent evaporation method for all the formulations from F1 to F9. Formulations F1, F2 and F3 were prepared Venlafaxine HCl with Chitosan polymer in the ratio of 1: 1, 1: 2 and 1: 3.Formulations F4, F5 and F6 were prepared Venlafaxine HCl with Sodium alginate polymer in the ratio of 1:1, 1:2 and 1:3; and formulations F7, F8 and F9 were prepared Venlafaxine HCl with Xanthan gum polymer in the ratio of 1: 1, 1: 2 and 1: 3 respectively: Based on the in vitro drug release characteristics and entrapment efficiency, the formulation F3 was found to be best formulation. By increasing the concentration of polymer, decreased the rate of drug released. According to stability study it was found that there was no variation in Percentage yield, Entrapment efficiency, and in vitro drug released profile of selected formulation F3 at specified period. Drug and Polymer interaction for formulated SR microsphere embedded on Venlaflaxin Hydrochloride was characterized by FT-IR and DSC studies.: The result showed that there is no interaction between the drug and polymer. Surface morphology of formulation carried out by SEM showed good spherical geometry and uniformity in size and shape. The formulation F3 was concluded best formulation among the prepared formulations.

 Keywords: Microspheres; Drug Loading; Venlaflaxin Hydrochloride; Drug Release; Sustained Release

References

  1. Senthil A., et al. “Design and optimization of mucoadhesive microspheres of Venlaflaxin HCl using 23 full factorial designs”. Der Pharmacia Lettre 3 (2011): 202-211.
  2. Syed MA., et al. “Complexation between Venlafaxine Hydrochloride and βCyclodextrin Structural Study by Nuclear Magnetic Resonance Spectroscopy”. Bulletin of the Korean Chemical Society 27 (2006): 1397.
  3. Patel NM and Soniwala MM. “Influence of release enhancers on release of Venlafaxine hydrochloride from glyceryl behenate matrix tablet”. Indian Drugs 45 (2008): 104.
  4. Holliday SM and Benfieid P. “Venlafaxine A review of its pharmacology and therapeutic potential in depression”. Drugs 49 (1995): 280-295.
  5. Hanekamp BB., et al. “Serotonin syndrome and rhabdomyolysis in venlafaxine poisoning a case report Netherlands’s”. The Journal of Medical Sciences 63 (2005): 316-318.
  6. Sundraganapathy , et al. “Development and Validation of UV Spectrophotometric Method for the Determination of Venlafaxine Hydrochloride in Bulk and Solid Dosage Forms”. International Journal of Pharmacy and Industrial Research 1 (2011): 28-31.
  7. Kumar Darapu BN., et al. “Formulation and In-Vitro Evaluation of Gastroretensive Floating Microspheres of Ranitidine Hydrochloride”. Research Journal of Pharmaceutical, Biological and Chemical Sciences (2011): 789-801.
  8. Bindumadhavi , et al. “Formulation and Evaluation of Venlafaxine Hcl Microspheres”. Hygeia Journal for Drugs and Medicines (2011): 64-70.
  9. Venkatesan P., et al. “Preparation and Evaluation of Sustained Release Loxoprofen”. Journal of Basic and Clinical Pharmacy (2011): 159-162.
  10. Prasant K , et al. “Effect of Method of Preparation on Physical Properties and Invitro Drug Release Profile of Losartan Microspheres a Comparative Study”. International Journal of Pharmacy and Pharmaceutical Sciences (2009): 208-228.
  11. Kishore Kumar Reddy , et al. “Formulation and Evaluation of Metformin Hydrochloride Microspheres”. International Journal of Pharmacy and Technology (2011): 2228-2247.

Citation

Citation: Janga Rameshbabu., et al. “Design, Characterisation and Evaluation of Venlafaxine Hydrochloride Sustained Release Microspheres". Acta Scientific Pharmaceutical Sciences 7.9 (2023): 42-50.

Copyright

Copyright: © 2023 Janga Rameshbabu., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate32%
Acceptance to publication20-30 days

Indexed In




News and Events


Contact US