Microbiota in the Era of COVID-19. Correlation and Benefits
Mohamed Raslan1, Eslam MS1, Sara AR1 and Nagwa A Sabri2*
1Drug Research Centre, Cairo, Egypt
2Department of Clinical Pharmacy, Faculty of Pharmacy - Ain Shams University, Cairo, Egypt
*Corresponding Author: Nagwa A Sabri, Professor, Department of Clinical Pharmacy, Faculty of Pharmacy - Ain Shams University, Cairo, Egypt.
June 06, 2022; Published: June 23, 2022
Background: SARS-CoV-2 is considered one of the most widely spread viral infections globally. The relation between diminished gut microbiota and susceptibility to Corona virus 2019 infection is well correlated. We aimed to investigate of the correlation between gut microbiota imbalance and the development of several diseases including COVID-19 with suggestion of routes for restoring this imbalance in affected patients especially geriatric ones.
Discussion: Resulting immune disruption from COVID-19 infection can alter gut microbiota leading to dysbiosis and increases gut permeability leading to progression of secondary bacterial infections and bacterial pneumonia. Besides, dysbiosis may lead to development of inflammatory bowel diseases, cardiovascular diseases, and autoimmune diseases. Diet changes and supplementation can positively affect dysbiosis state.
Conclusion: Diets like cereals, fruits, vegetables, and whole grain cereal are main contributor in restoring gut microbiota balance, on the other hand, diets containing high fat content are unfavorable due to their negative effect on microbiota diversity. Moreover, massive use of antibiotics is not recommended and was proven to affect gut microbiota abundance and balance leading to several inflammatory diseases. Finally, probiotics and prebiotics are proven to regulate bacterial balance and reduce probability of bacterial and viral infections.
Keywords: COVID-19; Gut Microbiota; Antibiotics; Probiotics; Prebiotics; Crohn’s Disease
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