Green Synthesis of Uracil Derivatives, DNA Binding Study and Docking-based Evaluation of their Anti-cancer and Anti-viral Potencies
Vadivelan Rengasamy1, Mohd Suhail2* and Arvind Jain1
1Department of Chemistry, School of Basic and Applied Sciences, Galgotias University UP, India
2Department of Chemistry, Jamia Millia Islamia, (A Central University) New Delhi, India
*Corresponding Author: Mohd Suhail, Department of Chemistry, Jamia Millia Islamia, (A Central University) New Delhi, India.
November 22, 2021; Published: December 22, 2021
In the last few decades, the world has faced a lot of major diseases such as cancer, AIDS and COVID-19. With the advent of disease, different medicines were also worked on but not every medicine could work against more than one major disease. Thus, the world needs such medicine that could act alone against different diseases with different mechanisms at the same time. In this condition, uracil derivatives also known as nucleoside derivatives came as a ray of hope, and have played an important role to cure many diseases. Hence, new twelve uracil derivatives were synthesized by a highly efficient one-pot inexpensive method successfully. It is fully confirmed that one-pot synthesis not only produces a maximum yield of products but also gives insights into green chemistry due to the reduction in byproducts, waste, energy and cost. Moreover, as per literature data, uracil derivatives (i) bind with DNA in the cancer-curing step, and (ii) interrupt the replication process of the virus during antiviral activity. Hence, DNA binding study was also done experimentally, whose results suggest that the reported compounds bind to DNA through intercalation modes. Only three out of twelve drugs were found to have a greater affinity towards DNA, which were selected for the docking study so that the binding pockets of DNA for the selected drugs, can be evaluated. The docking results exposed the formation of DNA-compound adduct. Furthermore, by following the same method, a docking study between newly synthesized drugs and their target during the antiviral action, were also done. It revealed that newly synthesized drugs may also exhibit antiviral activity.
Keywords: Uracil Derivatives; DNA Binding Study; Docking Study; Anti-cancer; Anti-HIV
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