B Manasa1*, Dr. V Shanmugam2 and P Prakash3
1M. Pharmacy, Department of Pharmaceutics, Sri Padmavathi School of Pharmacy, Jawaharlal Nehru Technological University, Anantapur, India
2M. Pharm, (Ph.D.) Assistant Professor, Sri Padmavathi School of Pharmacy, Jawaharlal Nehru Technological University, Anantapur, India
3M. Pharm, Assistant Professor, Sri Padmavathi School of Pharmacy, Jawaharlal Nehru Technological University, Anantapur, India
*Corresponding Author: Dattatreya Mukherjee, Intern at First Affiliated Hospital of Jinan University and Research Scholar at International School, Jinan University, P.R China.
Received: July 20, 2020; Published: December 09, 2021
Proniosomes are vesicular systems, in which the vesicles are made up of non-ionic based surfactants, cholesterol and other additives. Semisolid liquid crystal gel (proniosomes) prepared by dissolving the surfactant in a minimal amount of an acceptable solvent, namely ethanol and then hydration with least amount of water to form a gel. Itraconazole is a BCS class-II Triazole anti fungal drug having greater first pass metabolism and lesser bioavailability. The Present study was aimed at preparing six formulations of Topical Proniosomal gels with different concentrations of surfactants and cholesterol. All the prepared formulations were evaluated for, % Entrapment efficiency, In-vitro drug release studies, FT-IR studies, Vesicle size analysis Scanning electron microscopy and In vitro anti fungal studies. Among all the formulations IPN6 was found to exhibit optimum results for all the evaluation tests and In vitro drug release was found to be 90.10% at the end of 8th hour. The drug release of all formulations followed Higuchi kinetics on fitting the drug release data to various kinetic models. Thus Proniosomal gels are the promising approach for Itraconazole to overcome the gastrointestinal side effects and to increase the drug bioavailability.
Keywords: Itraconazole; Proniosomal Gel; Coacervation Phase Separation Method; Non Ionic Surfactants; Soyalecithin; Cholesterol
Citation: B Manasa., et al. “Formulation and Evaluation of Itraconazole Proniosomal Gel for Topical Drug Delivery". Acta Scientific Pharmaceutical Sciences 6.1 (2022): 18-43.
Copyright: © 2022 B Manasa., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.