Drug Delivery Via Lyotropic Liquid Crystals: An Innovative Approach
Anureet Kaur1, Lakhvir Kaur1*, Gurjeet Singh1, RK Dhawan2 and Ayushi Mahajan1
1Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, India
2Department of Pharmacology, Khalsa College of Pharmacy, Amritsar, India
*Corresponding Author: Lakhvir Kaur, Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, India.
July 16, 2021; Published: August 31, 2021
The lyotropic liquid crystal are self-assembled mesophases that exhibit the properties of both crystalline solid and isotropic liquids. They can potentially deliver hydrophilic, lipophilic, amphiphilic molecules including proteins and peptides. The unique structure of liquid crystals facilitates the improved drug loading and controlled release of the drug. Liquid crystals are widely explored for topical delivery of drugs because of their strong bio-adhesive property and resemblance to the structure of the biological membrane when applied topically. The biological membrane like structure of LLC improves the skin retention and permeation of the drugs. Lyotropic liquid crystals are mainly classified into three main categories i.e., lamellar, hexagonal and cubic. The structural difference between various types of liquid crystals can be determined by using a number of characterization techniques such as transmission electron microscopy, small angle x-ray diffraction and polarized light microscopy. In this review, we have discussed the classification, preparation and characterization of liquid crystals along with their various therapeutic applications. We have discussed the potential effect of liquid crystals in brain targeting via intranasal route and its applications in targeting various types of tumour cells.
Keywords: Lyotropic Liquid Crystals; Cubosomes; Hexosomes; Transdermal Delivery; Brain Targeting; Tumour Targeting
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