Sushant Kumar¹*, Kamla Pathak¹, NV Satheesh Madhav², Anurag Verma³ and Swarnima Pandey⁴

¹Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, UP, India
²Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, India
³Faculty of Pharmacy, Teerthankar Mahaveer University, Moradabad, UP, India
⁴Goel Institute of Pharmacy & Science, Dr. APJAKT University, Lucknow, India

*Corresponding Author: Sushant Kumar, Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, U.P., India.

Received: April 28, 2021; Published: June 03, 2021

Abstract

Background: As the lamotrigine is poorly water soluble drug. The dug was characterized for different physico-chemical properties and nanosized by solvent evaporation sonication technique.

Aims and Objectives: This research was aimed to reduce the model particle size and evaluate the diffusion study.

Methods: In the research work the bath sonication was done at 250 hertz frequency at room temperature. During sonication 25ml of purified water as added slowly drop by drop till turbidity was observed. The obtained residue was then centrifuged for 30 minutes at 4000 rpm for complete recovery of nanosized drug.

Results: Lamotrigine was found to be very soluble in methanol, soluble in phosphate buffer pH7.4 solution. It was found to be sparingly soluble in 0.1MHCl, phosphate buffer, pH 5.8 solutions. The nanosizing of drug particle was confirmed when the number of sonication cycles was increased up to 15 cycles as optimized, the %transmittance was found to increase proportionally.

Conclusion: This diffusion was in significant amount and confirmed that the nanosized drug easily pass through the biomembrane and can be targeted to desired sites in significant amount.

Keywords: Lamotrigine; Nanosizing; SEM Testing; Diffusion; Solubility

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Citation

Citation: Sushant Kumar., et al. “Nanosizing of Model Drug: Characterization and Evaluation of Nanosized Model Drug Diffusion through Biomembrane". Acta Scientific Pharmaceutical Sciences 5.7 (2020): 34-40.

Copyright

Copyright: © 2020 Sushant Kumar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.