Abstract

Wound care considered as a significant challenge in diabetic patients. Gradual progression of ulcer healing process in diabetes mellitus causes chronic wound infection and leads to amputation consequently. Neuropathy and angiopathy resulting from hyperglycemia are the main explanation of wound problems in these cases.

Phytochemical research showed that Oenothera biennis L (Evening Primrose) had a beneficial effect on inflammatory pathways and neuropathy in chronic disease such as diabetes. The most common mechanism of Evening Primrose (EP) extracts raised from its rich content of linolenic acids.

Here, we implemented an in vivo investigation to study the effect of EP oil on wound healing in alloxan-induced diabetic SW1 mice models. Results assessed by the degree of wound closure and histomophological scores analysis. The outcomes compare with zinc oxide as a conventional wound treatment remedy. Angiogenesis and population of essential cells in the tissue repair such as neutrophils, macrophages and fibroblasts in treated and control groups compare statistically.

The results showed accelerated new granulation tissue, wound closure and better histopathologic score throughout EP oil treatment than zinc oxide and control group after 7 and 14 days after wounding. We expect wound healing property of EP oil arising from modulating inflammation and alteration of cell membrane content according to its essential fatty acids specially Gamma-linolenic acid.

Keywords: Diabetic Wound Healing; Oenothera biennis L.; Evening Primrose Oil; Zinc Oxide

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Citation

Citation: Ramin Farhoudi., et al. “Oenothera biennis L. Oil Extract Accelerated Wound Healing in Diabetic Mice Models: A Histomorphological Study". Acta Scientific Pharmaceutical Sciences 4.8 (2020): 98-106.

Copyright

Copyright: © 2020 Ramin Farhoudi., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.