Saswata Rabi1, Sabina Yasmin2, Foni Bushon Biswas2, Rahul Das2, Debashis Palit2 and Tapashi Ghosh Roy1*
1Department of Chemistry, Chittagong University of Engineering and Technology, Bangladesh
2Department of Chemistry, University of Chittagong, Bangladesh
*Corresponding Author: Tapashi Ghosh Roy, Department of Chemistry, Chittagong University of Engineering and Technology, Bangladesh.
Received: June 27, 2020; Published: July 23, 2020
The hexamethyl tetraazamacrocyclic ligand salt, Me6diene. 2HClO4(L.2HClO4) has been synthesized by the condensation of ethylenediamine and acetone in the presence of HClO4, then two isomeric ligands tet-a and tet-b have been isolated from its reduced form. These ligands produced bimetallic and monometallic nitratozinc(II) complexes with Zn(NO3)2.6H2O. The nitratozinc(II) complexes, [(ZnL)2(NO3)](ClO4)3, [Zn(tet-a)(NO3)2] and [Zn(tet-b)(NO3)2] underwent axial addition and substitution reactions with KX (X= SCN, NO2, I or Br) in proper ratio to produce twelve new corresponding monometallic six coordinated octahedral complexes. The newly prepared complexes have been characterized on the basis of elemental analyses, IR, UV-Vis, and 1H-NMR spectroscopic, magnetic and molar conductivity data. Antibacterial activities of the ligands and complexes against different gram positive and gram negative bacteria have been investigated.
Keywords: Macrocyclic Ligands; Zinc(II) Complexes; Axial Addition and Substitution; Spectroscopic Studies; Antibacterial Activities
Citation: Tapashi Ghosh Roy., et al. “Tetraazamacrocyclic Ligands and their Zinc(II) Complexes: Synthesis, Characterization and Biological Activities". Acta Scientific Pharmaceutical Sciences 4.8 (2020): 42-54.
Copyright: © 2020 Tapashi Ghosh Roy., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.