Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 8 Issue 4

ECG Abnormalities in Patients on Psychotropics Medications: A Prospective Observational Study

Tanishq Mahajan1, Dhruvendra Lal2*, Aman Bharti3, Amaneet Kaur1, Poonam Bharti4, Kavisha Kapoor Lal5

1Postgraduate student, Department of Psychiatry, Maharishi Markandeshwar Institute of Medical Sciences and Research, MMDU, Ambala, Haryana, India
2Assistant Professor, Department of Community Medicine, Dr B R Ambedkar State Institute of Medical Sciences, SAS Nagar, Mohali, Punjab, India
3Assistant Professor, Department of Medicine, Guru Gobind Singh Medical College, Faridkot, Punjab, India
4Head, Department of Psychiatry, Maharishi Markandeshwar Institute of Medical Sciences and Research, MMDU, Ambala, Haryana, India
5Assistant Professor, Department of Periodontics, Himachal Dental College, Sundernagar, HP, India

*Corresponding Author: Dhruvendra Lal, Assistant Professor, Department of Community Medicine, Dr B R Ambedkar State Institute of Medical Sciences (AIMS) , Mohali, Punjab, India.

Received: March 06, 2024; Published: March 20, 2024


Objectives: Patients with mental illness are at an increased risk of cardiovascular changes, which can lead to mortality, and the use of psychotropic medications can exacerbate these risks. Various types of psychotropic drugs can have anticholinergic and antimuscarinic effects, leading to sinus tachycardia, while SSRIs may cause mild bradycardia. Tricyclic antidepressants can prolong the QRS interval and cause conduction defects, which is especially harmful for those with preexisting cardiac conduction delay and can lead to heart block.
The purpose of this study was to investigate the diverse ECG changes among outpatients who had been taking psychotropic medications for over a year and their association with other variables.

Material and Methods: A prospective observational study with patients on psychotropics for more than one-year was conducted in a tertiary care hospital.

Results: 125 psychiatric patients of which 53.60% (n = 67) were males and 46.40% (n = 58) were females. It was observed that out of 65 participants on antipsychotics 15.38% had abnormal ECG (Electrocardiogram) whereas among 60 participants on antidepressants 13.33% showed abnormal ECG. It was also seen that of 120 patients on benzodiazepine, 16.67% had ECG changes. Patients on psychotropics other than the above mentioned were 63 in number and constituted 20.63% of abnormal ECG changes.

Conclusion: ECG changes were observed in 15% to 20% of the patients who were started on psychiatric medicines. The changes were more among participants on antipsychotics (19.1%) followed by benzodiazepines (15.4%).

Keywords: ECG; Psychotropic; Antipsychotics; Medication; Cardiac Manifestation; Side Effects


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Citation: Dhruvendra Lal., et al. “ECG Abnormalities in Patients on Psychotropics Medications: A Prospective Observational Study".Acta Scientific Paediatrics 7.4 (2024): 20-29.


Copyright: © 2024 Dhruvendra Lal.,et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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