Acta Scientific PAEDIATRICS (ISSN: 2581-883X)

Editorial Volume 6 Issue 2

Therapeutic Hypothermia in LMIC: A Conundrum for Today or Forever?

Chakradhar Maddela*

Neonatologist and Echocardiologist, Manikrishna Hospital, Metpally, Jagitial District, Telangana, India

*Corresponding Author: Chakradhar Maddela, Neonatologist and Echocardiologist, Manikrishna Hospital, Metpally, Jagitial District, Telangana, India.

Received: December 31, 2022; Published: January 01, 2023


Therapeutic hypothermia (HT) is a trusted and specific therapy of neuroprotection for babies with perinatal asphyxia. This therapy should be initiated within 6hrs, preferably within 3hrs (Thoresen M 2013) [1] after primary hypoxic ischemic insult (the sentinel event) in moderate to severe HIE term/near term infants after satisfying the cooling criteria. It involves in maintaining the core body temperature of the baby at 33.5°C for 72 hours. This is followed by gradual rewarming.


  1. Thoresen M., et al. “Time is Brain: Starting Therapeutic Hypothermia within Three Hours after Birth Improves Motor Outcome in Asphyxiated Newborns”. Neonatology 104 (2013): 228-233.
  2. Jacobs SE., et al. “Cooling for newborns with hypoxic ischemic encephalopathy (Review)”. CDSR 1 (2013): CD003311.
  3. Pouliah SS., et al. “Therapeutic Hypothermia for Neonatal Encephalopathy in low to middle income countries: A systematic review and meta-analysis”. PLOS ONE (2013).
  4. Thayyil S., et al. “Hypothermia for moderate to severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Srilanka, and Bangladesh”. The Lancet Global Health 9 (2021).
  5. Chakradhar Maddela. “Enhanced Post-Resuscitation Neonatal Care in Possibly Hypoxic Neonates at Resource Limited Setting: A Systematic Review”. Acta Scientific Paediatrics 7 (2021): 77-86.
  6. Chakradhar Maddela. “A Comprehensive Clinical Approach to Hypoxic Ischemic Encephalopathy in Term Infants: A Review”. Acta Scientific Paediatrics2 (2012): 37-44.


Citation: Chakradhar Maddela. “Therapeutic Hypothermia in LMIC: A Conundrum for Today or Forever?". Acta Scientific Paediatrics 6.2 (2023): 01.


Copyright: © 2023 Chakradhar Maddela. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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