Clinical Profile of Children with SARS-CoV-2 Infection from a Tertiary Centre in Western India During the First Wave of COVID-19 Pandemic
Sumant Patil1*, Gayatri Bhide2, Rajan Joshi3 and Pratibha Phasale4
1Consultant Paediatric Intensivist, Department of Paediatrics, Deenanath Mangeshkar Hospital and Research Centre, Pune, Maharashtra, India
2Consultant Paediatrician, Department of Paediatrics, Deenanath Mangeshkar Hospital and Research Centre, Pune, Maharashtra, India
3Consultant Paediatrician, Head of the Department of Paediatrics, Deenanath Mangeshkar Hospital and Research Centre, Pune, Maharashtra, India
4DNB Resident, Department of Paediatrics, Deenanath Mangeshkar Hospital and Research Centre, Pune, Maharashtra, India
*Corresponding Author: Sumant Patil, Consultant Paediatric Intensivist, Department of Paediatrics, Deenanath Mangeshkar Hospital and Research Centre, Pune, Maharashtra, India.
September 24, 2021; Published: November 17, 2021
Background: Limited data have emerged describing the presentation and clinical characteristics of the paediatric patients with SARS CoV-2 infection. Majority of this data was from the initial part of the pandemic and mainly from China, some from Europe and USA, although none significant from the Indian sub-continent.
Aim : To describe clinical profile of paediatric SARS CoV-2 infection from a tertiary centre in western India covering the first active duration of COVID -19 pandemic.
Material and Methods: Retrospective observational cohort study over 6 months from 1st April 2020 to 30th September 2020.
- Children aged 0 to <18 years, admitted in hospital with COVID-19 infection.
- Positive for SARS-CoV-2 infection using RT-PCR or rapid antigen test from oropharyngeal and nasopharyngeal swabs.
Results: 148 children hospitalised with confirmed SARS CoV-2 infection were included with median age of 8.07 years (IQR 3.07 to 13.11 years) and sex ratio of 1.42 males per female. Of these 57(38.5%) were asymptomatic and 91(61.5%) were symptomatic. Fever was the commonest presenting feature in 65(43.9%), followed by cough 34(23%) and runny nose in 25(16.9%). Pediatric intensive care unit admission was needed in 9(6.1%) patients and there was one neonatal death.
Conclusion: This study confirms that the pattern of disease presentation is mild in pediatric population with a high number of asymptomatic patients and exceedingly rare mortality due to SARS-CoV-2 infection.
Keywords: COVID-19; SARS-CoV-2; RT-PCR; Rapid Antigen Test; Clinical Profile in Children
- Wang C., et al. “A novel coronavirus outbreak of global health concern”. Lancet 10223 (2020): 470-473.
- Adhikari SP., et al. “Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review”. Infectious Diseases of Poverty 1 (2020): 29.
- Shekerdemian LS., et al. “Characteristics and outcomes of children with coronavirus disease 2019 (COVID-19) infection admitted to US and Canadian pediatric intensive care units”. JAMA Pediatrics9 (2020): 868-873.
- Zimmermann P and Curtis N. “Coronavirus infections in children including COVID-19: An overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children”. Pediatric Infectious Disease Journal 39 (2020): 355.
- A Hoang., et al. “COVID-19 in 7780 pediatric patients: a systematic review”. EClinicalMedicine 24 (2020).
- Bailey LCRH., et al. “Assessment of 135794 pediatric patients tested for Severe Acute Respiratory Syndrome Coronavirus 2 across the united states”. JAMA Pediatrics2 (2020): e205052.
- Gotzinger Florian., et al. “COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study”. The Lancet Child and Adolescent Health9 (2020): 653-661.
- Song W., et al. “Clinical features of pediatric patients with coronavirus disease (COVID-19)”. Journal of Clinical Virology (2020): 104377.
- Sisk B., et al. “National Trends of Cases of COVID-19 in Children Based on US State Health Department Data”. Pediatrics 6 (2020): e2020027425.
- Ding Y., et al. “Clinical characteristic of children with COVID-19; a meta-analysis”. Frontiers in Paediatrics 8 (2020): 431.
- Badal S., et al. “Prevalence, clinical characteristics and outcome of pediatric COVID-19 : a systematic review and meta-analysis”. Journal of Clinical Virology 135 (2020): 104715.
- https://covid19.who.int WHO Coronavirus Disease (COVID-19) dashboard (2021).
- https://www.covid19maharashtragov.in/mh-covid/dashboard COVID-19 dashboard by Government of Maharashtra, India (2021).
- Hasell J., et al. “A cross-country database of COVID-19 testing”. Scientific Data 7 (2020): 345.
- Leidman E., et al. “COVID-19 trends among persons aged 0-14 years - United states, March 1-December 12,2020”. Morbidity and Mortality Weekly Report 70 (2021): 88-94.
- Swann OV., et al. “Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study”. BMJ 370 (2020): m3249.
- Dong Y., et al. “Epidemiology of COVID-19 Among Children in China”. Pediatrics 145 (2020): e20200702.
- Lu X., et al. “SARS-CoV-2 infection in children”. The New England Journal of Medicine 382 (2020): 1663-1665.
- N Kumar., et al. “Descriptive epidemiology of SARS-COV-2 infection in Karnataka state South India: Transmission dynamics of symptomatic vs. asymptomatic infections”. EClinicalMedicine-The Lancet100717 (2021).
- Soni SL., et al. “Demographic and clinical profile of patients with COVID-19 at a tertiary care hospital in north India”. Indian Journal of Medical Research (2020).
- Bhandari ., et al. “Clinical Profile of Covid-19 Infected Patients Admitted in a Tertiary Care Hospital in North India”. Journal of the Association of Physicians of India 5 (2020): 13-17.
- DeBiasi RL., et al. “Severe COVID-19 in children and young adults in the Washington, DC metropolitan region”. Journal of Pediatrics 223 (2020): 199-203.
- Liu WJ., et al. “T-cell immunity of SARSCoV: Implications for vaccine development against MERS-CoV. Antiviral Research 137 (2017): 82-92.
- Henry BM., et al. “Laboratory abnormalities in children with novel coronavirus disease 2019”. Clinical Chemistry and Laboratory Medicine 58 (2020): 1135-1138.
- BK Tsankov., et al. “Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and Meta-Analysis”. International Journal of Infectious Diseases 103 (2021): 246-256.