Association of Different Post-Operative Complications with Cardiac Troponin
I and Cardiopulmonary Bypasses
Masroor H Sharfi*, Mohamed H Mashaly, Abdelmonem Helal, Abdullah A Al-Shehri, Osama Abdelaziz and Abdul Hadi Al-Ghamdi
Pediatric Cardiology Department, King Faisal Specialist Hospital and RC, Jeddah, Saudi Arabia
*Corresponding Author: Masroor H Sharfi, Assistant Consultant, Pediatric Cardiology Department, King Faisal Specialist Hospital and RC, Jeddah, Saudi Arabia.
Received:June 26, 2021; Published: July 14, 2021
Background: Cardiac troponin I (cT-I) is considered as gold standard due to its increased sensitivity and specific markers for myocardial infraction and accordingly, it is used in the diagnosis of myocardial infarction in patients with acute coronary syndrome. Necrosis and myocardial damage occur as a result of conditions following postoperative myocardial ischemia.
Objective: This study is aimed to examine association between elevated cardiac troponin-I (cT-I) levels as cardiac biomarker and its association with the development of post cardiac surgery complications after cardiopulmonary bypass in paediatric population.
Methodology: This prospective study was conducted to monitor cardiopulmonary bypass post-operative complications in response to cardiac troponin-I (cT-I) levels in paediatric population to examine, particular patterns prognostic significance.
Results: A total of 190 paediatric patients with congenital heart defect were enrolled in the study. Most frequently observed cardiac lesion in CPB group was atrial septal defect (ASD) 27% and ventricular septal defect (VSD) 5% in CPB with ventricular incision group. A significant correlation was observed in both acute kidney injury incidence (P < 0.01) in both CPB and CPB with ventricular incision groups. Also, statistically significant correlation was observed in both groups in relation to hypo perfusion injuries increasing admission duration to CTICU (P < 0.03).
Conclusion: The current study confirmed that cT-I trends correlate with clinical outcome in paediatric patients with cardiopulmonary bypass specially in post-operative prognostic monitoring. The rate of morbidity and mortality in the patients diagnosed with myocardial injury can be decreased by improving perioperative management.
Keywords: Cardiopulmonary Bypass; Cardiac Troponin-I; Sensitivity
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