Md. Mostafijur Rahman1,a, Saimon Miah1,a, Sonia Tamanna1, Md. Bayejid Hosen1, Tasnin Akter1, TH Johra2, Yearul Kabir1 and M Zakir Hossain Howlader1*
1Laboratory of Nutrition and Health Research, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh
2Consultant, Department of Obstetrics and Gynecology, Islami Bank Hospital, Dhaka, Bangladesh
aAuthors contributed equally in this study
*Corresponding Author: M Zakir Hossain Howlader, Professor, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh.
Received: October 29, 2020; Published: November 27, 2020
Background: Vitamin D deficiency during pregnancy leads to poor neonatal development which has serious consequences during the later part of life. The aim of the study was to evaluate maternal and umbilical cord blood 25[OH] D concentrations and their association with birth weight.
Methods: Pre-delivery maternal venous blood within a week before delivery and paired matched neonatal cord blood samples were collected from 75 pregnant women. Serum 25[OH] D was measured by high-performance liquid chromatography. Serum calcium, phosphorus, and alkaline phosphatase activity were measured by colorimetric methods.
Results: Mean maternal serum 25[OH] D was 46.45 ± 5.02 ng/ml, and cord blood 25[OH] D was 21.89 ± 2.27 ng/ml. The serum 25[OH] D level of the mothers and the neonates were significantly associated (P < 0.01) with a linear correlation coefficient of r = 0.49. The mean birth weight of neonates was 2.83 kg ± 0.38 and 22% of the neonates had low birth weight (LBW) (2.33 ± 0.17). Average birth weight of normal babies was 2.97 ± 0.30. The mean maternal 25[OH] D level of mothers with normal birth weight babies (n = 58; 77.33%) was significantly higher (50.41 ± 5.00 ng/mL) than that (28.24 ± 6.87 ng/mL) of mothers with LBW babies (p < 0.0001). There was a high degree of positive correlation between maternal 25[OH] D status with neonate’s birth weight (r = 0.593, p < 0.01).
Conclusion: The results obtained in this study show that there is significant correlation between maternal vitamin D with neonatal birth weight in a cross-sectional urban population of Bangladesh.
Keywords: Serum 25[OH] D; Pregnancy; Cord Blood; Low Birth Weight
Citation: M Zakir Hossain Howlader., et al. “Association of Maternal Vitamin D with Neonatal Vitamin D Status and Birth Weight in Urban Population of Bangladesh: A Cross Sectional Study". Acta Scientific Paediatrics 3.12 (2020): 19-26.
Copyright: © 2020 M Zakir Hossain Howlader., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.