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Acta Scientific Paediatrics

Research Article Volume 1 Issue 2

Effect of Phototherapy Treatment of Neonatal Jaundice on Blood Endothelin and Nitric Oxide Levels: Clinical Significance in Preterm Infants

Doaa M Youssef1*, Muftah Th Ben Yousef1, Amal S Alshal2 and Abdel-Raziq El-Shiekh1

1Pediatric Department, Zagazig University, Egypt
2Assistant Professor of Biochemistry, Zagazig University, Egypt

*Corresponding Author: Doaa M Youssef, Pediatric Department, Zagazig University, Egypt.

Received: July 27, 2018; Published: August 22, 2018

Citation: Doaa M Youssef., et al. “Effect of Phototherapy Treatment of Neonatal Jaundice on Blood Endothelin and Nitric Oxide Levels: Clinical Significance in Preterm Infants”. Acta Scientific Pediatrics 1.2 (2018).

  Neonatal hyperbilirubinemia is one the commonest cause of admission in NICU, phototherapy is the golden stand red therapy long time ago, which showed efficacy and it's side effects should be studied in depth. Both nitric oxide (NO) and endothillin1 (ET1) are potent vasodilation and vasoconstrictor which may be affected by phototherapy; so we aimed to investigate impact of phototherapy on their levels both in full term and preterm and if there is relation with hemodynamical stability in treated neonates. In this study we tested 38 neonate before and after phototherapy and We measured NO and ET1 levels also we assessed Heart rate blood pressure before and after therapy, we found significant rise in both NO and ET1 after phototherapy both in full term and preterm with no difference between full term and preterm, we found also a significant correlation between each of age, Heart rate and diastolic blood pressure and each of NO and ET1, but there is no significant correlation of systolic blood pressure and both NO and ET1. We concluded that we have to monitor heart rate and blood pressure specially diastolic in neonates treated with phototherapy for hyperbilirubinemia as they may be affected as a result of effect of phototherapy on both NO and ET1.


Copyright: © 2018 Doaa M Youssef., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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