R Janknegt1*, R Fijn2, HC Alblij3 and AA Van Bodegraven4
1Hospital Pharmacist/Clinical Pharmacologist, Sittard-Geleen, The Netherlands
2Hospital Pharmacist, Clinical Pharmacologist, Alrijne Healthcare Group, Leiden, The Netherlands
3Internist, Nephrologist, Alrijne Healthcare Group, Leiderdorp, The Netherlands
4Gastroenterologist, Zuyderland Medical Center, Heerlen-Sittard-Geleen, The Netherlands
*Corresponding Author: R Janknegt, Hospital Pharmacist/Clinical Pharmacologist, Sittard-Geleen, The Netherlands.
Received: May 25, 2021; Published: July 26, 2021
Objectives: This analysis was performed to compare intravenous iron formulations for the treatment of iron deficiency anaemia when oral iron preparations are ineffective, contraindicated or not tolerated in any other way.
Methods: In this study intravenous iron formulations are compared by means of the SOJA method.
The following selection criteria were applied: licenced indications, contraindications, warnings and precautions, number of formulations, drug interactions, clinical efficacy, adverse effects, safety, tolerability, ease of admininstration and documentation.
Results: Overall SOJA scores differed slightly, with Ferric derisomaltose showing the highest score, followed by Ferric carboxymaltose. The scores for the other formulations were lower, especially because of the lower ease of administration.
Acquisition cost was not taken into account, because this varies with time. In practice acquisition cost is of course an important selection criterion. Exclusion of this criterion also makes this comparison more internationally applicable..
Conclusion: The present matrix may be of use for hospital formulary committees in determining preferences for specific iron formulations from a clinical practice, prior to the procurement phase.
Keywords: Intravenous Iron Formulations; Drug Selection; Ferric Carboxymaltose; Ferric Dextran Complex; Ferric Derisomaltose; Iron Sucrose
Citation: R Janknegt., et al. “Intravenous Iron Formulations: Drug Selection by Means of the SOJA Method".Acta Scientific Pharmacology 2.8 (2021): 26-47.
Copyright: © 2020 R Janknegt., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.