Agreema Badhu¹, Balbir Singh², Pardeep Deewan³, Anand Aggarwal¹*, Divjot Kaur¹, Kamalinder Kaur¹, Aman Kalia¹, Chiman Lal¹, Gurpreet Kaur¹ and Akash¹

¹Department of Ophthalmology, Government Medical College, Patiala, India
²Member Legislative Assembly and Honorable Health Minister, Vidhan Sabha Punjab, Chandigarh, India
³Director, Maharaj Charan Singh Charitable Multispecialty Hospital, Beas, Punjab, India

*Corresponding Author: Anand Aggarwal, Cornea, Glaucoma and Refractive Surgery Services, Department of Ophthalmology, Government Medical College Patiala, Punjab 147001, India.

Received: August 17, 2025; Published: August 28, 2025

Abstract

Purpose: To evaluate the efficacy of Ripasudil, a Rho-kinase inhibitor, in managing pseudophakic corneal edema following cataract surgery and comparison with the conventional treatment.

Methods: In this prospective interventional study, 104 patients with pseudophakic corneal edema were divided into two groups end were administered either 0.4% Ripasudil ophthalmic solution (Group A) or 5% hypertonic saline (Group B). Visual acuity, central corneal thickness (CCT), and intraocular pressure (IOP) were evaluated along with time taken for resolution of corneal edema over a period of six months.

Results: Significant improvements in BCVA, corneal clarity and CCT were observed in both groups, with slightly earlier improvements in Group A which was not statistically significant. No serious adverse effects were reported.

Conclusion: Ripasudil 0.4% ophthalmic solution is not inferior to 5% hypertonic saline drops in improving visual outcomes and reducing corneal edema in patients with pseudophakic corneal edema following cataract surgery and that it is safe, effective, and potentially offers endothelial benefits. It may serve as a non-invasive therapeutic alternative in pseudophakic corneal edema.

Keywords: Cornea; Central Corneal Thickness (CCT)

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Citation

Citation: Anand Aggarwal., et al. “Effect of Ripasudil on Visual Outcomes in Pseudophakic Corneal Edema: A Prospective Interventional Study".Acta Scientific Ophthalmology 8.9 (2025): 21-33.

Copyright

Copyright: © 2025 Anand Aggarwal., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.