Abstract

We report a case of post-operative corneal epithelial toxicity following intra operative subconjunctival use of Mitomycin C for 1.5 minutes in twin site phacoemulsification and Trabeculectomy. Patient was doing well till 15 days after the surgery with the clear cornea and 20/20 vision. Then he noticed diminution of vision and cornea showed multiple punctate corneal erosion. On persistence of the lesion till five weeks after the surgery corneal scraping was done and sent for histopathological examination which showed Mitomycin related toxicity. With proper diagnosis and treatment patient improved well with a central clear cornea and vision 20/30. With guarded use and keen eye for possible complications in the follow-up visits one can avoid the undesirable and hazardous effects of MMC.

Keywords: Corneal Epithelial Toxicity; Mitomycin C; Trabeculectomy

References

1. Singh P and Singh A. “Mitomycin-C Use in Ophthalmology”. IOSR Journal of Pharmacy 3 (2013).
2. Wilkins M., et al. “Intra-operative mitomycin C for glaucoma surgery”. The Cochrane Database of Systematic Reviews 1 (2001): CD002897.
3. Chen TC., et al. “Long-term follow-up of initially successful trabeculectomy”. Ophthalmology 7 (1997): 1120-1125.
4. Oram O., et al. “Necrotizing Keratitis Following Trabeculectomy With Mitomycin Archives of Ophthalmology”. American Medical Association 113 (O1995): 19-20.
5. Hau S and Barton K. “Corneal complications of glaucoma surgery”. Current Opinion in Ophthalmology 20 (2009): 131-136.
6. Coppens G and Maudgal P. “Corneal complications of intraoperative Mitomycin C in glaucoma surgery”. Bulletin de la Societe Belge d'ophtalmologie 314 (2010): 19-23.
7. Dadeya S and Fatima S. “Corneoscleral perforation after pterygium excision and intraoperative mitomycin C”. Ophthalmic Surgery, Lasers and Imaging Retina 2 (2003): 146-148.
8. Kymionis GD., et al. “Dry eye after photorefractive keratectomy with adjuvant mitomycin C”. Journal of Refractive Surgery5 (2006): 511-513.
9. Kremer I., et al. “Delayed epithelial healing following photorefractive keratectomy with mitomycin C treatment”. Acta Ophthalmologica 3 (2012): 271-276.
10. Sagara H., et al. “Sodium hyaluronate eye drops prevent late-onset bleb leakage after trabeculectomy with mitomycin C”. Eye 4 (2008): 507-514.

Citation

Citation: Lalitha KJ., et al. “Corneal Epithelial Toxicity Following Intraoperative Use of Mitomycin C during Trabeculectomy - A Case Report".Acta Scientific Ophthalmology 4.6 (2021): 53-56.

Copyright

Copyright: © 2021 Lalitha KJ., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.