Priya Singh¹ and Deepak Goel^2*

¹Senior Resident Neurology, Department of Neurology Himalayan Institute of Medical Sciences, Dehradun, India
²DM Neurology, Professor, Department of Neurology Himalayan Institute Of Medical Sciences, Dehradun, Indi

*Corresponding Author: Deepak Goel, DM Neurology, Professor, Department of Neurology Himalayan Institute Of Medical Sciences, Dehradun, India.

Received: September 07, 2026; Published: September 29, 2026

Background: Cerebral small vessel disease (CSVD) is associated with two clinical subtypes; 1) acute stroke and 2) chronic progressive cognitive decline or gait disorder. Radiological markers of CSVD are; lacunar stroke, lacunes, white matter hyperintensity (WMH), enlarges perivascular spaces (EPVS), and cerebral microbleeds (CMBs).

Aims and Objectives: This study was aimed to find out the various clinical types of CSVD and association with demographic and radiological parameters.

Methods: all patients with acute stroke, progressive gait disorder or cognitive decline having CSVD changes on MRI were evaluated for various clinical, demographic and radiological parameters at admission and after 3 months. At the end of 3 months patient’s quality of life, activity of daily living, cognitive scores and modified Rankin scores were calculated.

Results: Study performed on 80 patients of cerebral small vessels disease (CSVD) showed few interesting observations. In our cohort, chronic progressive disease was more frequent and was found in 45 (56.25%) patients and rest 35 (43.75%) presented as acute stroke. Among chronic progressive group, progressive cognitive decline was more frequent as compare to progressive gait abnormality (64% versus 36%).

Conclusions: The chronic progressive disease is commoner with progressive cognitive decline as most common type of CSVD. Poor control of hypertension, diabetes, drug compliance and quality of sleep were the most common risk factor found for worsening of CSVD patients. Radiological markers like worsening WMH, EPVS, and high total CSVD scores were associated with poor outcome and high dependency of patients at 3 months follow-up.

Keywords: Cerebral Small Vessel Disease (CSVD); White Matter Hyperintensity (WMH);

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Citation

Citation: Priya Singh and Deepak Goel. “Phenotypic and Radiological Correlation of Clinical Presentation and Outcome of Patients with Cerebral Small Vessel Disease (CSVD)". Acta Scientific Neurology 9.10 (2026): 07-18.

Copyright

Copyright: ©2026 Priya Singh and Deepak Goel. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.