Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Case Report Volume 7 Issue 2

Awake Craniotomy with Neuronavigation Mapping for Parietal Dysembroblastic Neuroepithelial Tumor (Dnet) Causing Intractable Sensory Seizures in an Adolescent - A Case Report

Venkatesan Sanjeevi and S Balaji*

Department of Neurosurgery, Meenakshi Mission Hospital, Madurai, India

*Corresponding Author: S Balaji, Department of Neurosurgery, Meenakshi Mission Hospital, Madurai, India.

Received: October 06, 2023; Published: January 06, 2024


Dysembryoplastic neuroepithelial tumours (DNET) are a rare, typically benign glial- neuronal cortical tumour that most commonly manifests in children and young adults as intractable seizures. The key benefit of awake craniotomy in multi-drug resistant intractable seizures caused by DNET in eloquent areas especially in and around motor cortex is to do safe maximal resection, preserving motor functions and seizure free outcome. A 16 year old adolescent presented with refractory sensory seizures for 7 years. MRI Brain was done showing left parietal lesion suggestive of DNET with focal cortical dysplasia (FCD). Awake craniotomy was done with the help of neuronavigation and gross total resection of lesion was achieved. Biopsy reported as DNET with FCD. Post operatively patient was seizure free. DNET associated with FCD in parietal region is very rare. Cortical dysplasia is commonly associated with DNET and appears to contribute to the DNET's epileptogenic activity. For optimal disease treatment, surgical treatment should aim to remove DNET with FCD. We found awake craniotomy with neuronavigation helps to resect the lesion maximally with no or minimal neurological deficits.

Keywords: Awake Craniotomy; Sensory Seizures; Neuronavigation; Dysembryoblastic Neuroepithelial Tumor (DNET); Focal Cortical Dysplasia (FCD)


  1. Daumas-Duport C., et al. “Dysembryoplastic neuroepithelialtumour”. In: Kleihues P, Cavenee WK, Pathology and genetics of tumours of the nervous system. Lyon, France: IARC (2000): 103-106.
  2. Cervera-Pierot P., et al. “Dysembryoplastic neuroepithelial tumors located in the caudate nucleus area: report of four cases”. Neurosurgery 5 (1997): 1065-1070.
  3. Frater JL., et al. “Surgical pathological findings of extratemporal-based intractable epilepsy: a study of 133 consecutive resections”. Archives of Pathology and Laboratory Medicine 124 (2000): 545-549.
  4. Lee J., et al. “Dysembryoplastic neuroepithelial tumors in pediatric patients”. Brain and Development 9 (2009): 671-681.
  5. Prayson RA and Estes ML. “Cortical dysplasia: a histopathologic study of 52 cases of partial lobectomy in patients with epilepsy”. Human Pathology 5 (1995): 493-500.
  6. Kaufman WE and Galaburda “Cerebrocortical microdysgenesis in neurologically normal subjects: A histopathologic study”. Neurology 39 (1989): 238-244.
  7. Daumas-Duport C., et al. “Dysembryoplastic neuroepithelial tumour: a surgically curable tumor of young patients with intractable partial seizures”. Neurosurgery 5 (1988): 545-556.
  8. Koeller KK and Henry “Superficial Gliomas: Radiologic- Pathologic Correlation”. RadioGraphics 21.6 (2001): 1533-1556.
  9. Takahashi A., et al. “Frequent association of cortical dysplasia in dysembryoplastic neuroepithelial tumor treated by epilepsy surgery”. Surgical Neurology International 5 (2005): 419-427.
  10. Hong SC., et al. “Surgical treatment of intractable epilepsy accompanying cortical dysplasia”. Journal of Neurosurgery 93 (2000): 766 -


Citation: Venkatesan Sanjeevi and S Balaji. “Awake Craniotomy with Neuronavigation Mapping for Parietal Dysembroblastic Neuroepithelial Tumor (Dnet) Causing Intractable Sensory Seizures in an Adolescent - A Case Report". Acta Scientific Neurology 7.2 (2024): 08-11.


Copyright: © 2024 Venkatesan Sanjeevi and S Balaji. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate32%
Acceptance to publication20-30 days

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is May 30, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US