Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Letter to Editor Volume 7 Issue 1

The APOE and MTHF Genes' Potential Role and Contribution to an Increased Risk of Vascular Dementia

Ivan Barbov1-3 and Goce Kalcev3

1University Clinic of Neurology, Skopje, Republic of North Macedonia
2Faculty of Medicine, St. Cyril and Methodius-Skopje, Skopje, Republic of North Macedonia
3National Alliance for Neuromuscular Diseases and Neuroscience, GANGLION Skopje, Skopje, Republic of North Macedonia

*Corresponding Author: Goce Kalcev, National Alliance for Neuromuscular Diseases and Neuroscience, GANGLION Skopje, Skopje, Republic of North Macedonia.

Received: October 06, 2023; Published: January 01, 2024

Abstract

As life expectancy rises, the global number of dementia patients is expected to rise to 81.1 million by 2040. Vascular dementia (VaD) is traditionally regarded as the second most common cause of dementia after Alzheimer's disease (AD) [1]. It is essential to identify VaD risk factors in order to develop effective preventive and treatment strategies. Polygenetic influences may lead to a predisposition to developing VaD, according to epidemiological and animal studies

References

  1. Arvanitakis Zoe., et al. “Diagnosis and Management of Dementia: Review”. JAMA16 (2019): 1589-1599.
  2. Rohn Troy T. “Is apolipoprotein E4 an important risk factor for vascular dementia?” International Journal of Clinical and Experimental Pathology7 (2014): 3504-3511.
  3. Pitas RE., et al. “Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B, E (LDL) receptors in the brain”. The Journal of Biological Chemistry29 (1987): 14352-14360.
  4. Laitinen, M H et al. “Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study”. Dementia and Geriatric Cognitive Disorders1 (2006): 99-107.
  5. Nilsson Karin., et al. “Plasma homocysteine levels and different forms of vascular disease in patients with dementia and other psychogeriatric diseases”. Dementia and Geriatric Cognitive Disorders 1 (2009): 88-95.
  6. Elkins Jacob S., et al. “Methylenetetrahydrofolate reductase C677T polymorphism and cognitive function in older women”. American Journal of Epidemiology6 (2007): 672-678.
  7. Peng Qiliu., et al. “The MTHFR C677T polymorphism contributes to increased risk of Alzheimer's disease: evidence based on 40 case-control studies”. Neuroscience Letters 586 (2015): 36-42.

Citation

Citation: Ivan Barbov and Goce Kalcev. “The APOE and MTHF Genes' Potential Role and Contribution to an Increased Risk of Vascular Dementia". Acta Scientific Neurology 7.2 (2024): 01-02.

Copyright

Copyright: © 2024 Ivan Barbov and Goce Kalcev. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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