Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Research Article Volume 6 Issue 10

Visuo-Spatial Impairment in Patients Who Recovered from Lassa Fever Infection: A 30 Day Follow Up Observatory Study

Sunmonu Taofiki Ajao1*, Owhin Sampson Omagbemi1, Abejegah Chukwuyem2, Kareem Adesola Olawumi2, Etafo Ijeoma2 and Ogunmodede Adebimpe Funmilola3

1Department of Medicine, Federal Medical Centre Owo, Ondo State, Nigeria
2Department of Community Health, Federal Medical Centre, Owo, Ondo State, Nigeria
3Department of Medicine, Federal Medical Centre, Owo, Ondo state, Nigeria

*Corresponding Author: Sunmonu Taofiki Ajao, Department of Medicine, Federal Medical Centre, Owo, Ondo State, Nigeria.

Received: August 21, 2023; Published: September 22, 2023


Introduction: Lassa Fever infection is one of the viral haemorrhagic fevers that occur in epidemics in west African countries. It could affect the central nervous system and present with cognitive function impairment.

Aims and Objective: This study aimed to examine the visuo-spatial function in patients who recovered from Lassa fever infection especially within the 30 day follow up period.

Methods and Materials: Fifty patients who presented with serologically positive Lassa fever infection were studied along with fifty age, sex and educationally matched controls. The sociodemographic and clinical variables of the participants were obtained with structured questionnaire. Thereafter the patients were examined neurologically. and automated neuropsychological test were administered to all study participants. Blood samples were also collected from the patients for HIV and Hepatitis virus screening. Blood samples forSerum electrolytes, Urea and creatinine and full blood count were also collected. The results obtained were documented and analyzed with SPSS version 21.0 (Chicago Illinois).

Results: The mean age of the Lassa Fever patients was 41.94 ± 14.5years while that of the normal controls was 37.34+12.89 (p > 0.05). There were 27 males and 23 females in the Lassa fever group while there were 30 males and 16 females in the control group. The mean CVST time in the Lassa group was 22.59 ± 10.89 seconds while that of the control group was 17.89 ± 6.55 seconds (p < 0.05). Only prolonged hospital stay was associated with significantly prolonged mean CVST time (p < 0.05). The serum electrolytes level, degree of anaemia serum urea and creatinine had no impact on the patients mean CVST mean time . The prevalence of severely prolonged mean CVST time in the patients with Lassa fever was 18.8% while that of controls was 8%.

Conclusion: Prolonged mean CVST time was observed in patients from acute Lassa fever infection with recovery. Prolonged hospital stay was identified as a significant risk factor for this

Keywords: Cognition; Viral Haemorrhagic Fever; Lassa Fever


  1. Centre for Disease control (DSC). Lassal fever (2023).
  2. World Health organization (WHO). Seasonal Variations in Lassa fever epidemics (2023).
  3. Bakare EA., et al. “Mathematical modelling and analysis of transmission dynamics of lassa fever”. Journal of Applied Mathematics (2020): 6131708.
  4. Okokhere F., et al. “Clinical and Laboratory predicators of Lassa Fever outcome in a dedicated facility in Nigeria; an observational cohort study”. Lancet Infectious Disease 18 (2018): 687-695.
  5. Okokhere PO and Akpede GO. “Central nervous system manifestation of Lassa fever in Nigeria and the effect on mortality”. Journal of the Neurological Sciences 1 (2013): ebo4.
  6. ‘The Iron Psyche’. A system for automated neuropsychological testing (2023).
  7. Goldstein G and Kgc F. “Performance of Brain damaged schizophrenia and normal subjects on a visual searching task”. Perceptional and Motor Skills 45 (1978): 731-734.
  8. Da Mita MA., et al. “The validity of a computerized searching task as an indicator of brain damage”. Behavior Research methods and Intrumentation 13 (1981): 592-594.
  9. Ogunrin O., et al. “Predictive Validity and usefulness of visual scanning task in HIV/AIDS A case-control analysis”. African Journal of Neurological Sciences1 (2007): 1-7.
  10. Aldenkamp AP., et al. “The cognitive impact of epiletiform EEG discharges: Relationship with type of cognitive task”. Child Neuropsychology4 (2004): 297-305.
  11. Botch TL., et al. “Active Visual search in naturalistic environments reflects individual difference in classic visual search performance”. Scientific Report 13 (2023): 631.
  12. Moreland MC., et al. “A neuropsychological test battery for the Apple Ile”. International Journal of Man-Machine Studies 25 (1986): 453-467.
  13. Ulasi I. “Gender bias in access to health care in Nigeria. A study of end-stage renal disease”. Tropical Doctor1 (2008): 50-52.
  14. Odelola TD. “Healthcare utilization among rural women of child- bearing age; a Nigerian experience”. Pan African Medical Journal (2015): 171.
  15. Awosanya EJ. “Post –epidemic awareness and knowledge of Lassafever among residents of affected community in Ibadan, Oyo state”. Veterinary World8 (2018): 1059-1063.
  16. Horn Sd., et al. “The relationship between severity of illness and hospital length of stay and mortality medical Care”. 29.4 (1991): 305.
  17. Setareh M., et al. “Severity of Illness affecting the length of stay and outcomes in patients admitted to intensive care units, Iran 2019”. Journal of Education and Health Promotion 10 (2021): 142.
  18. Plante J., et al. “Cognitive impairment and length of stay in acute care hospitals: A scoping review of the literature”. Anadian Journal of Aging/La Revue Canadianne av vitalissement 3 (2019): 405-423.
  19. Ogunniyi A., et al. “Influence of education on aspects of cognitive functions in non – demented elderly Nigerians”. Neuroepidemiology5-6 (1991): 246-250.
  20. Rijnen SJM., et al. “Evaluation of normative data of a widely used copmuterized neuropsychological test battery Applicability and effect of sociodemographic variables in a Dutch Sample”. Assessment2 (2020): 373-383.
  21. Corlier FW. “Principal component analysis suggests multiple dimensions of memory inhabitation are differently affected by age”. Frontiers in Psychology (2023): 13.
  22. Rondanelh M., et al. “Electrolytes and cognitive function in the elderly; relationship between serum sodium and chloride concentration and psychometric scores”. Panminerva Medica3 (1998): 191-195.
  23. Bialecka Debek A and Pietruszka B. “The association between hydration status and cognitive function among free-living elderly, volunteers”. Aging, Clinical and Experimental Research 31 (2019): 695-703.
  24. Brin Kkoeter RT., et al. “Impact of resolution of hyponatraemia on neurocognitive and motor performance in geriatric patients”. Scientific Reports1 (2019): 12526.
  25. Lee S., et al. “Serum sodium in relation to various domains of cognitive function in the elderly US population”. BMC Geriatrics 21 (2021): 328.
  26. Saponaro F., et al. “Serum calcium levels are associated with cognitive functions in hypoparathyroidism; an neuro – psychological study in an Italian cohorts of patients with chronic post surgical hypoparathyroidism”. Journal of Endocrinological Investigation 10 (2021): 1909-1918.
  27. Owolabi LF., et al. “Cognitive functions assessment in patients with end stage renal disease in Nigeria: A single centre experience”. Annals of African Medicine13 (2016): 138-144.
  28. Egbi OG., et al. “Prevalence and determination of cognitive impairment in patients with chronic Kidney disease; a cross-sectional study in Benin – City, Nigeria”. Annals of African Medicine2 (2015): 75-81.
  29. Sunmonu TA., et al. “Cognitive functions in patients with newly diagnosed HIV infection in a tertiary health facility in south – west Nigeria. Assessment using computer assisted neuropsychological test battery”. eNuerological Science 3 (2016): 54-59.
  30. Qin T., et al. “Association between anaemia and cognitive decline among middle- aged elderly; evidence from Chinese health and retirement Longitudinal study”. BMC Geriatrics 19 (2019): 305.
  31. Kuter DJ., et al. “Cognitive impairment among patients with chronic immune”. Thrombocytetopemia Blood 140 (2022): 8422-8424.


Citation: Sunmonu Taofiki Ajao., et al. “Visuo-Spatial Impairment in Patients Who Recovered from Lassa Fever Infection: A 30 Day Follow Up Observatory Study". Acta Scientific Neurology 6.10 (2023): 17-24.


Copyright: © 2023 Sunmonu Taofiki Ajao., et al.This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate32%
Acceptance to publication20-30 days

Indexed In

News and Events

Contact US