V Rama Raju*

Professor of Computer Science and Engineering, Computational Neuroscience, and Cognitive System, CMR College of Engineering and Technology (UGC Autonomous), Kandlakoya (V), Medchal Rd., Hyderabad, Telangana, India

*Corresponding Author: V Rama Raju, Professor of Computer Science and Engineering, Computational Neuroscience, and Cognitive System, CMR College of Engineering and Technology (UGC Autonomous), Kandlakoya (V), Medchal Rd., Hyderabad, Telangana, India.

Received: March 18, 2022; Published: April 29, 2022

Abstract

Development of neuro protection has turn out to be the focal point of endeavors targeted at reducing the progress of Parkinson disease or Parkinson`s disease (PD) signs and symptoms which are fundamental feature manifestations characterized by the four classes of motoric (motor) symptoms of PD, namely tremor, Bradykinesia (akinesia), postural instability and rigidity. One of the most common neurologic disorders that elders experience, Parkinson disease is a dreadful diagnosis impacting nearly - circa ~2of every 00 adult-subjects more than 60 years old older-adults. Even though there is presently no-cure as well as existing PD-treatments improve relieve only the motor-symptoms rather than the disease’s progression, therefore, a bright possibility lies in latest research experimental investigational studies concentrating upon the neuro protection. This article study the provocative pathways that lead to the development of deep brain stimulation of the subthalamic nucleus, a surgical procedural method (with which an innocuous microelectrode is implanted into the region of substantia nigra) which reduces Parkinson tremors and restores motor-function in patients with advanced idiopathic Parkinson's disease. PD, the causes of which are not known, is a chronic, progressive brain disorder that belongs to a larger class of disorders called movement disorders. In PD, one population of brain cells-those that produce a chemical messenger called dopamine-become impaired and are lost over time. The loss of these brain cells causes circuits in the brain to function abnormally, and those abnormal circuits result in movement problems.

Keywords: Deep Brain; Provocative; Neuroprotection; Parkinson’s Disease

References

1. Venkateshwarla Rama Raju., et al. “Effect of Microelectrode Recording in Accurate Targeting STN with High Frequency DBS in Parkinson Disease”. IETE Journal of Research (2019).
2. Venkateshwarla Rama Raju., et al. “Adaptive Closed-Loop Deep Brain Stimulator Coding Techniques for Target Detections in Parkinson’s”. IETE Journal of Research (2021).
3. Dabbeta Anji Reddy., et al. “Deep Brain Stimulation Coding in Parkinson’s: An Evolving Approach”.  IETE Journal of Research (2021).
4. V Rama Raju. “A Clinico-Statistical Analysis of Writer’s Cramp Signals: Study with Indigenously Developed Multi-Channel Intramuscular EMG”. IFMBE Proceedings (2019).
5. , et al. “Principal Component Latent Variate Factorial Analysis of MER Signals of STN-DBS in Parkinson's Disease (Electrode Implantation)”. IFMBE Proceedings (2018).
6. Venkateshwarla Rama Raju. “The Probablistic Random Forest Clinico-Statistical Regression Analysis of MER Signals with STN-DBS and Enhancement of UPDRS Published”. IFMBE Proceedings (2019).
7. Venkateshwarla Rama Raju. “Latent Variate Factorial Principal Component Analysis of Microelectrode Recording of Subthalamic Nuclei Neural Signals with Deep Brain Stimulator in Parkinson Disease”. Springer Briefs in Applied Sciences and Technology (2019).
8. V Rama Raju., et al. “Microrecording of Writer's Cramp Signals with Indigenously Developed Advanced Real-Time Multi-Channel Intelligent-EMG-System”. Proceedings of the Intelligent Systems Conference (Intellisys) Published (2017).
9. V Rama Raju. “The Role of Microelectrode Recording (MER) in STN DBS Electrode Implantation (2015).
10. Rama Raju V. “Design and Development of Advanced Multi-channel EMG Micro Electrode Recording System”. In: Lhotska L., Sukupova L., Lacković I., Ibbott G. (eds) World Congress on Medical Physics and Biomedical Engineering 2018”. IFMBE Proceedings2 (2019).
11. V Rama Raju. “Stimulations to Basal Ganglia and the Efficiency of Microminiaturized Electrode Recording (MER) to Quantify STN Neurons with Deep Brain Stimulator (DBS)- the Lead Point in Parkinson Diseased Conditions (2015).
12. V Rama Raju. “Mirror Movements in Writer’s Cramp-A Study with Multi-Channel EMG (2013).
13. V Rama Raju. “EMG-EMG Coherence in Multisite Writer’s Cramp Waveforms - A Study with Advanced Multi-Channel EMG System (2015).
14. V Rama Raju. “Mirror Movements in Writer's Cramp - Study with Advanced Real-Time Multi-Channel EMG (A Clinico-Statistical Analysis) (2015).
15. V Rama Raju. “The Role of Microelectrode Recording (MER) in STN DBS Electrode Implantation.
16. V Rama Raju. “Latent variate factorial principal component analysis of microelectrode recording of subthalamic nuclei neural signals with deep brain stimulator in Parkinson disease.
17. V Rama Raju. “Effectiveness of Lead Point with Microrecording for Determining STN-DBS in Parkinson disease using HM-Models”. IRJET- International Research Journal of Engineering and Technology (IRJET) (2019).
18. R Jankovic J. “Parkinson’s disease: clinical features and diagnosis”. Journal of Neurology, Neurosurgery, and Psychiatry 79 (2008): 368-376.
19. Fahn S and Elton RL. “The Unified Parkinsons Disease Rating Scale. Recent developments in Parkinsons disease. Florham Park, N.J: Macmillan Healthcare Information (1987): 153-63.
20. Antoniades CA and Barker RA. “The search for biomarkers in Parkinsons disease: a critical review”. Expert Reviews 12 (2008): 1841-1852.
21. Morgan JC., et al. “Biomarkers in Parkinsons disease”. Current Neurology and Neuroscience Reports 10 (2010): 423-430.
22. Evelyn Strauss., et al. “Lasker~DeBakey Clinical Medical Research Award to Alim Louis Benabid and Mahlon DeLong (2014): 1-4.
23. Amirnovin R., et al. “Experience with microelectrode guided subthalamic nucleus deep brain stimulation”. Neurosurgery1 (2006): ONS96-102.
24. Kyriaki Kostoglou. “Classification and Prediction of Clinical Improvement in Deep Brain Stimulation from Intraoperative Microelectrode Recording”. IEEE Transactions on Biomedical Engineering 5 (2017): 1123-1130.
25. Sang Jin Kim., et al. “Effects of Subthalamic nucleus stimulation on motor cortex plasticity in Parkinson disease”. Neurology 85 (2015): 425-432.
26. Bour LJ., et al. “Long term experience with intraoperative microrecording during DBS neurosurgery in STN and Gpi”. Acta Neurochirurgica 12 (2010): 2069-2077.
27. Zuan He. “Neural Signal processing of microelectrode recordings for deep brain stimulation”. Chalmers University of Technology (2009).
28. AL Benabid. “Deep brain stimulation for Parkinson’s disease”. Current Opinion in Neurobiology 6 (2003): 696-706.
29. AL Benabid., et al. “Acute and long-term effects of subthalamic nucleus stimulation in Parkinson’s disease”. Stereotactic and Functional Neurosurgery 1-4 (1994): 76-84.
30. A Moran., et al. “Subthalamic nucleus functional organization revealed by Parkinsonian neuronal oscillations and synchrony”. Brain12 (2008): 3395-3409.
31. GL Defer. “Core assessment program for surgical intervention therapies in Parkinson’s disease”. Movement Disorders 4 (1999): 572-584.
32. Andrade-Souza YM., et al. “Comparison of three methods of targeting the subthalamic nucleus for chronic stimulation in Parkinson's disease”. Neurosurgery 2 (2008): 875-883.
33. Larry Squire., et al. “Fundamental Neuroscience, 4^th Edition”. AP Academic Press (2012).
34. McClelland S. “A cost analysis of intraoperative microelectrode recording during subthalamic stimulation for Parkinson’s disease”. Movement Disorders (2011).
35. William H Press., et al. “Numerical Recipes in C++, Cambridge University Press” (2002).
36. Andrzej Dobrowolski., et al. “Spectral Analysis of Motor Unit Action Potentials”. IEEE Transactions on Biomedical Engineering 12 (2007): 2300-2302.
37. Sabato Santaniello., et al. “Therapeutic mechanisms of high-frequency stimulation in Parkinson`s disease and neural restoration via loop-based reinforcement”. Proceedings of the National Academy of Sciences (2015): 1-10.
38. Sridevi V Sarma., et al. “Using point process models to compare neural spiking activity in the subthalamic nucleus of Parkinson`s patients and a healthy primate”. IEEE Transactions on Biomedical Engineering 6 1297-1305.
39. Hans S., et al. “Electrical stimulation inhibits cytosine arabinoside-induce neuronal death by preventing apoptosis in dorsal root ganglion neurons”. NeuroReport16 (2016): 1217-1224.
40. V Rama Raju., et al. “Latent Variate Factorial Principal Component Analysis of Microelectrode Recording of Subthalamic Nuclei Neural Signals with Deep Brain Stimulator in Parkinson Diseaseet.al. Springer Briefs in Forensic and Medical Bioinformatics”. Soft Computing and Medical Bioinformatics (2018).
41. V Rama Raju. “Principal component latent variate factorial analysis of MER signals of STN-DBS in Parkinson`s disease (Electrode Implantation)”. Springer Nature 68.3 (2018).
42. V Rama Raju., et al. “The Role of Microelectrode Recording (MER) in STN DBS Electrode Implantation”, IFMBE Proceedings, Springer, Vol. 51”. World Congress on Medical Physics and Biomedical Engineering (2015): 1204-1208.
43. https://www.laskerfoundation.org/awards/2014_c_description.htm

Citation

Citation: V Rama Raju. “Deep Brain Stimulation: A Provocative Pathways and Neuroprotection - The Focus of Efforts Aimed at Slowing the Progression of Parkinson’s Disease - Part I". Acta Scientific Neurology 5.5 (2022): 59-65.

Copyright

Copyright: © 2022 V Rama Raju. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.