Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Case Report Volume 4 Issue 12

Headache and MTHFRT677T Genotype in a Young Woman - Clinical Case

Damelan Kombate1*, Sirui Zhou2, Seylom Kossi Biosse3, Agbémélé K M Soedje3, Kossivi Apetse3, Komi Assogba3, Koffi AA Balogou3 and Guy A Rouleau2

1Department of Neurology, University of Kara, Togo
2Teaching Hospital Campus, Neurology Department, University of Lomé, Togo
3Montreal Neurological Institute and Hospital, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada

*Corresponding Author: Damelan Kombate, Department of Neurology, University of Kara, Togo.

Received: June 20, 2021; Published: November 12, 2021


Introduction: The MTHFRC677T polymorphism is involved in several pathologies.

Objectives: We report one case of headache associated with the MTHFR T677T genotype in a woman.

Observation: A 39-year-old woman was admitted in neurology department on March 12, 2012 for headaches with feet and hands parathesia for several months. The physical examination had noted a decrease in osteotendinous reflexes and an abolition of the plantar cutaneous reflex. Hamilton’s 17-item depression score was 7. In the etiological investigation of probable polyneuropathy, homocysteine was 88.39 μmol/l (standard < 15 μmol/l), folates 2.34 nmol/l (standard ≥ 11 nmol/l) and vitamin B12 132 pmol/l (standard ≥ 147 pmol/l). The aetiological investigation of this hyperhomocysteinemia revealed an MTHFRT677T genotype.

Conclusion: The MTHFRT677T genotype is associated with a variety of manifestations ranging from metabolic (B12 deficiency), headache and polyneuropathies.

Keywords: MTHFR Polymorphism; Headache; Polyneuropathy


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Citation: Damelan Kombate., et al. “Headache and MTHFRT677T Genotype in a Young Woman - Clinical Case”. Acta Scientific Neurology 4.12 (2021): 37-40.


Copyright: © 2021 Damelan Kombate., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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